PMID- 19589359
OWN - NLM
STAT- MEDLINE
DCOM- 20100112
LR  - 20221207
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 205
IP  - 1
DP  - 2009 Dec 14
TI  - Effects of chronic intracerebroventricular 3,4-methylenedioxy-N-methamphetamine 
      (MDMA) or fluoxetine on the active avoidance test in rats with or without 
      exposure to mild chronic stress.
PG  - 259-64
LID - 10.1016/j.bbr.2009.06.039 [doi]
AB  - In despite the similarity of mechanisms of action between both selective 
      serotonin reuptake inhibitors (SSRI) and MDMA (main compound of "Ecstasy") there 
      are relatively few reports on the effects of the later on animal models of 
      depression. There are many animal models designed to create or to assess 
      depression. Mild chronic stress (MCS) is a procedure designed to create 
      depression. MCS includes the chronic exposure of the animal to several stressors. 
      After that, rats show behavioural changes associated to depression. In the other 
      hand, the active avoidance task (AAT) is an experimental situation in which an 
      animal has to accomplish a particular behaviour in order to avoid the application 
      of a stressor. Animals exhibiting depression fail to acquire avoidance responses 
      as rapidly as normal animals do. In order to assess the effect of MDMA on the 
      acquisition of an active avoidance response, forty-five rats were divided in two 
      groups exposed or not exposed to MCS. Rats also received chronic 
      intracerebroventricular MDMA (0.2microg/microl; 1microl), fluoxetine 
      (2.0microg/microl; 1microl) or saline solution (0.9%; 1microl). Our results 
      showed that the effect of MDMA depends upon the level of stress. MDMA treated 
      animals showed better acquisition (F([2,37])=7.046; P=0.003) and retention 
      (F([2,37])=3.900; P=0.029) of the avoidance response than fluoxetine or saline 
      treated animals when exposed to MCS. This finding suggests that MDMA (and no 
      fluoxetine) was able to change the aversive valence of the stressors maybe 
      enhancing coping strategies. This effect could serve as a protective factor 
      against helplessness and maybe post-traumatic stress.
FAU - Leon, Laura A
AU  - Leon LA
AD  - Laboratory of Neuroscience and Behaviour, Department of Psychology, Universidad 
      de los Andes, Cra 1 #18A-12, Bogota, Colombia.
FAU - Landeira-Fernandez, Jesus
AU  - Landeira-Fernandez J
FAU - Cardenas, Fernando P
AU  - Cardenas FP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090707
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Serotonin Agents)
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - 01K63SUP8D (Fluoxetine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Avoidance Learning/*drug effects/physiology
MH  - Chronic Disease
MH  - Depression/drug therapy/physiopathology
MH  - Disease Models, Animal
MH  - Fluoxetine/administration & dosage/*pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*pharmacology
MH  - Neuropsychological Tests
MH  - Rats
MH  - Rats, Wistar
MH  - Reaction Time
MH  - Serotonin Agents/administration & dosage/*pharmacology
MH  - Selective Serotonin Reuptake Inhibitors/administration & dosage/*pharmacology
MH  - Stress, Psychological/*drug therapy/physiopathology
EDAT- 2009/07/11 09:00
MHDA- 2010/01/13 06:00
CRDT- 2009/07/11 09:00
PHST- 2009/05/02 00:00 [received]
PHST- 2009/06/24 00:00 [revised]
PHST- 2009/06/26 00:00 [accepted]
PHST- 2009/07/11 09:00 [entrez]
PHST- 2009/07/11 09:00 [pubmed]
PHST- 2010/01/13 06:00 [medline]
AID - S0166-4328(09)00399-4 [pii]
AID - 10.1016/j.bbr.2009.06.039 [doi]
PST - ppublish
SO  - Behav Brain Res. 2009 Dec 14;205(1):259-64. doi: 10.1016/j.bbr.2009.06.039. Epub 
      2009 Jul 7.