PMID- 19589953
OWN - NLM
STAT- MEDLINE
DCOM- 20091005
LR  - 20220316
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 107
IP  - 3
DP  - 2009 Sep
TI  - Protein and carbohydrate supplementation after exercise increases plasma volume 
      and albumin content in older and young men.
PG  - 770-9
LID - 10.1152/japplphysiol.91264.2008 [doi]
AB  - This study examined whether increased plasma volume (PV) and albumin content 
      (Alb(cont)) in plasma for 23 h after exercise were attenuated in older subjects 
      compared with in young adult subjects, and if this attenuation abated by 
      supplementation with protein and carbohydrate (CHO) immediately after exercise. 
      Eight moderately active older (approximately 68 yr) and 8 young (approximately 21 
      yr) men performed two trials: control (CNT) and Pro-CHO in which subjects 
      consumed placebo (0.5 kcal, 0 g protein, 0.5 mg Na(+) in 3.2 ml total fluid 
      volume/kg body wt) or protein and CHO mixture (3.2 kcal, 0.18 g protein, 0.5 mg 
      Na(+) in 3.2 ml total fluid volume/kg body wt) supplementations, respectively, 
      immediately after high-intensity interval exercise for 72 min [8 sets of 4 min at 
      70-80% peak oxygen consumption rate (Vo(2peak)) intermitted by 5 min at 20% 
      Vo(2peak)]. PV, Alb(cont), and plasma globulin content (Glb(cont)) were measured 
      before exercise, at the end of exercise, every hour from the 1st to the 5th hour 
      after exercise, and at the 23rd hour after exercise. From 12 h before the start 
      to the end of experiment, food intake was controlled to the age-matched 
      recommended dietary allowances. We found that during the first 4 h after exercise 
      in CNT, Alb(cont) recovered less in the older than the young group by 
      approximately 0.04 g/kg (P < 0.05), while it generally recovered more with 
      Pro-CHO than CNT by approximately 0.09 and approximately 0.04 g/kg in the young 
      and older group, respectively, accompanied by a greater increase in PV by 
      approximately 1 and approximately 2 ml/kg, respectively, during the 23 h after 
      exercise (P < 0.05). Glb(cont) remained constant throughout the experiment in 
      both trials for both age groups. Thus the attenuated responses of Alb(cont) and 
      PV after exercise in older subjects were restored by protein and CHO 
      supplementation immediately after exercise, similarly to young subjects.
FAU - Okazaki, Kazunobu
AU  - Okazaki K
AD  - Department of Sports Medical Sciences, Shinshu University Graduate School of 
      Medicine, Matsumoto 390-8621, Japan.
FAU - Hayase, Hideki
AU  - Hayase H
FAU - Ichinose, Takashi
AU  - Ichinose T
FAU - Mitono, Hiroyuki
AU  - Mitono H
FAU - Doi, Tatsuya
AU  - Doi T
FAU - Nose, Hiroshi
AU  - Nose H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090709
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Proteins)
RN  - 0 (Serum Albumin)
RN  - 9007-92-5 (Glucagon)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aging/*physiology
MH  - Anaerobic Threshold/physiology
MH  - Bicycling/physiology
MH  - Blood Pressure/physiology
MH  - Body Weight/drug effects/physiology
MH  - Dietary Carbohydrates/*pharmacology
MH  - Dietary Proteins/*pharmacology
MH  - *Dietary Supplements
MH  - Energy Intake/physiology
MH  - Exercise/*physiology
MH  - Glucagon/metabolism
MH  - Heart Rate/drug effects/physiology
MH  - Hematocrit
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Osmolar Concentration
MH  - Plasma Volume/*drug effects/*physiology
MH  - Serum Albumin/*metabolism
MH  - Urodynamics/drug effects/physiology
MH  - Water-Electrolyte Balance/drug effects/physiology
MH  - Young Adult
EDAT- 2009/07/11 09:00
MHDA- 2009/10/06 06:00
CRDT- 2009/07/11 09:00
PHST- 2009/07/11 09:00 [entrez]
PHST- 2009/07/11 09:00 [pubmed]
PHST- 2009/10/06 06:00 [medline]
AID - 91264.2008 [pii]
AID - 10.1152/japplphysiol.91264.2008 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 2009 Sep;107(3):770-9. doi: 
      10.1152/japplphysiol.91264.2008. Epub 2009 Jul 9.