PMID- 19590001
OWN - NLM
STAT- MEDLINE
DCOM- 20090722
LR  - 20220316
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 325
IP  - 5937
DP  - 2009 Jul 10
TI  - Caloric restriction delays disease onset and mortality in rhesus monkeys.
PG  - 201-4
LID - 10.1126/science.1173635 [doi]
AB  - Caloric restriction (CR), without malnutrition, delays aging and extends life 
      span in diverse species; however, its effect on resistance to illness and 
      mortality in primates has not been clearly established. We report findings of a 
      20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this 
      critical gap in aging research. In a population of rhesus macaques maintained at 
      the Wisconsin National Primate Research Center, moderate CR lowered the incidence 
      of aging-related deaths. At the time point reported, 50% of control fed animals 
      survived as compared with 80% of the CR animals. Furthermore, CR delayed the 
      onset of age-associated pathologies. Specifically, CR reduced the incidence of 
      diabetes, cancer, cardiovascular disease, and brain atrophy. These data 
      demonstrate that CR slows aging in a primate species.
FAU - Colman, Ricki J
AU  - Colman RJ
AD  - Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 
      53715, USA. rcolman@primate.wisc.edu
FAU - Anderson, Rozalyn M
AU  - Anderson RM
FAU - Johnson, Sterling C
AU  - Johnson SC
FAU - Kastman, Erik K
AU  - Kastman EK
FAU - Kosmatka, Kristopher J
AU  - Kosmatka KJ
FAU - Beasley, T Mark
AU  - Beasley TM
FAU - Allison, David B
AU  - Allison DB
FAU - Cruzen, Christina
AU  - Cruzen C
FAU - Simmons, Heather A
AU  - Simmons HA
FAU - Kemnitz, Joseph W
AU  - Kemnitz JW
FAU - Weindruch, Richard
AU  - Weindruch R
LA  - eng
GR  - RR020141-01/RR/NCRR NIH HHS/United States
GR  - P01 AG011915-11A29002/AG/NIA NIH HHS/United States
GR  - P01 AG011915/AG/NIA NIH HHS/United States
GR  - P01 AG-11915/AG/NIA NIH HHS/United States
GR  - C06 RR020141/RR/NCRR NIH HHS/United States
GR  - C06 RR015459/RR/NCRR NIH HHS/United States
GR  - P51 RR000167/RR/NCRR NIH HHS/United States
GR  - RR15459-01/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - *Aging
MH  - Animals
MH  - Atrophy/epidemiology/prevention & control
MH  - Body Weight
MH  - Brain/*pathology
MH  - *Caloric Restriction
MH  - Cardiovascular Diseases/epidemiology/*prevention & control
MH  - Diabetes Mellitus/epidemiology/*prevention & control
MH  - Female
MH  - Glucose/metabolism
MH  - Incidence
MH  - *Longevity
MH  - Macaca mulatta
MH  - Male
MH  - Neoplasms/epidemiology/*prevention & control
PMC - PMC2812811
MID - NIHMS170749
EDAT- 2009/07/11 09:00
MHDA- 2009/07/23 09:00
PMCR- 2010/01/28
CRDT- 2009/07/11 09:00
PHST- 2009/07/11 09:00 [entrez]
PHST- 2009/07/11 09:00 [pubmed]
PHST- 2009/07/23 09:00 [medline]
PHST- 2010/01/28 00:00 [pmc-release]
AID - 325/5937/201 [pii]
AID - 10.1126/science.1173635 [doi]
PST - ppublish
SO  - Science. 2009 Jul 10;325(5937):201-4. doi: 10.1126/science.1173635.