PMID- 19590244
OWN - NLM
STAT- MEDLINE
DCOM- 20100325
LR  - 20151119
IS  - 1661-7819 (Electronic)
IS  - 1661-7800 (Linking)
VI  - 97
IP  - 1
DP  - 2010
TI  - Effects of lutein on oxidative stress in the term newborn: a pilot study.
PG  - 36-40
LID - 10.1159/000227291 [doi]
AB  - BACKGROUND: Oxidative stress (OS) plays a crucial role in pathological conditions 
      during the early neonatal period. The newborns are susceptible to oxidative 
      damage due to high metabolic rate and low levels of antioxidant enzymes. Lutein 
      has been found to have protective functions in adult humans as antioxidant. AIM: 
      To evaluate the effects of lutein on OS in newborns. We tested the hypothesis 
      that lutein would act both by increasing antioxidant capacity and inhibiting OS. 
      METHODS: This was a randomized, double-blind, placebo-controlled, single-center 
      study. 20 healthy term newborns were assigned to receive lutein or placebo 
      (lutein and control group, respectively) at 12 and 36 h after birth. Total 
      hydroperoxides (TH), as marker of OS, and biological antioxidant potential (BAP), 
      as marker of antioxidant power, were detected on cord blood and at 48 h of life 
      in all babies. RESULTS: TH significantly increased from birth to 48 h in the 
      control group (p = 0.02), but not in the lutein group. In the lutein group, BAP 
      significantly increased after 48 h (p = 0.02), showing a strengthening of 
      antioxidant activity due to lutein. At 48 h of life, compared with those in the 
      control group, neonates assigned to receive lutein had significantly lower TH 
      levels (p = 0.04) and higher BAP levels (p = 0.028). CONCLUSIONS: Lutein 
      administration in newborns increases the levels of BAP decreasing TH. The 
      enhancement of antioxidant activity in plasma clearly results in protecting 
      newborn from perinatal OS. These preliminary results, adding a new contribution 
      in antioxidant strategies, strongly require to be confirmed by RCT.
CI  - Copyright 2009 S. Karger AG, Basel.
FAU - Perrone, Serafina
AU  - Perrone S
AD  - Division of Neonatology, Department of Pediatrics, Obstetrics and Reproductive 
      Medicine, Policlinico Le Scotte University of Siena, Siena, Italy.
FAU - Longini, Mariangela
AU  - Longini M
FAU - Marzocchi, Barbara
AU  - Marzocchi B
FAU - Picardi, Anna
AU  - Picardi A
FAU - Bellieni, Carlo V
AU  - Bellieni CV
FAU - Proietti, Fabrizio
AU  - Proietti F
FAU - Rodriguez, Antonello
AU  - Rodriguez A
FAU - Turrisi, Giovanni
AU  - Turrisi G
FAU - Buonocore, Giuseppe
AU  - Buonocore G
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20090707
PL  - Switzerland
TA  - Neonatology
JT  - Neonatology
JID - 101286577
RN  - 0 (Biomarkers)
RN  - 0 (Peroxides)
RN  - X72A60C9MT (Lutein)
SB  - IM
MH  - Apgar Score
MH  - Biomarkers/blood
MH  - Birth Weight
MH  - Double-Blind Method
MH  - Female
MH  - Fetal Blood/chemistry/metabolism
MH  - Gestational Age
MH  - Humans
MH  - Infant, Newborn
MH  - Lipid Peroxidation/drug effects/physiology
MH  - Lutein/*pharmacology
MH  - Male
MH  - Oxidative Stress/*drug effects/physiology
MH  - Peroxides/blood
MH  - Pilot Projects
MH  - Term Birth/*drug effects/metabolism
EDAT- 2009/07/11 09:00
MHDA- 2010/03/26 06:00
CRDT- 2009/07/11 09:00
PHST- 2008/09/08 00:00 [received]
PHST- 2008/12/15 00:00 [accepted]
PHST- 2009/07/11 09:00 [entrez]
PHST- 2009/07/11 09:00 [pubmed]
PHST- 2010/03/26 06:00 [medline]
AID - 000227291 [pii]
AID - 10.1159/000227291 [doi]
PST - ppublish
SO  - Neonatology. 2010;97(1):36-40. doi: 10.1159/000227291. Epub 2009 Jul 7.