PMID- 19590453
OWN - NLM
STAT- MEDLINE
DCOM- 20100514
LR  - 20091229
IS  - 1536-4801 (Electronic)
IS  - 0277-2116 (Linking)
VI  - 49
IP  - 4
DP  - 2009 Oct
TI  - Maternal HLA class I compatibility in patients with biliary atresia.
PG  - 488-92
LID - 10.1097/MPG.0b013e31819a4e2c [doi]
AB  - Biliary atresia (BA) is an inflammatory cholangiopathy of unknown etiology. 
      Maternal microchimerism has been identified in the livers of patients with BA. We 
      analyzed the human leukocyte antigen (HLA) compatibility between 57 BA 
      patient-mother pairs and 50 control-mother pairs. The HLA class I matching was 
      significantly more frequent in BA pairs (odds ratio [OR]=2.46) than controls. 
      Similar results were also found in child-to-mother HLA compatibility (OR=2.16). 
      Our results indicate that patients with BA have an immunogenetic histocompatible 
      relationship with their mothers, which may result in an increase in maternal 
      microchimerism found in BA.
FAU - Irie, Naoki
AU  - Irie N
AD  - Department of Anatomy and Developmental Biology, Graduate School of Medicine, 
      Kyoto University, Kyoto, Japan.
FAU - Muraji, Toshihiro
AU  - Muraji T
FAU - Hosaka, Naoki
AU  - Hosaka N
FAU - Takada, Yasutsugu
AU  - Takada Y
FAU - Sakamoto, Seisuke
AU  - Sakamoto S
FAU - Tanaka, Kohichi
AU  - Tanaka K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr Gastroenterol Nutr
JT  - Journal of pediatric gastroenterology and nutrition
JID - 8211545
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Bile Ducts
MH  - Biliary Atresia/*genetics/*immunology
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - *Chimerism
MH  - Female
MH  - HLA Antigens/*genetics
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility, Maternal-Fetal/*genetics
MH  - Humans
MH  - Liver Transplantation
MH  - Male
MH  - Mothers
MH  - Odds Ratio
MH  - Pedigree
EDAT- 2009/07/11 09:00
MHDA- 2010/05/15 06:00
CRDT- 2009/07/11 09:00
PHST- 2009/07/11 09:00 [entrez]
PHST- 2009/07/11 09:00 [pubmed]
PHST- 2010/05/15 06:00 [medline]
AID - 10.1097/MPG.0b013e31819a4e2c [doi]
PST - ppublish
SO  - J Pediatr Gastroenterol Nutr. 2009 Oct;49(4):488-92. doi: 
      10.1097/MPG.0b013e31819a4e2c.