PMID- 19591287
OWN - NLM
STAT- MEDLINE
DCOM- 20090903
LR  - 20110727
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 67
IP  - 7
DP  - 2009 Jul
TI  - [Anti-aging effects by caloric restriction].
PG  - 1366-71
AB  - Caloric restriction (CR) in experimental animals shows to extend the lifespan of 
      animals with the decreased frequency of age-related diseases. CR also produces 
      beneficial health effects in monkeys and humans. These benefits include improved 
      insulin sensitivity, enhanced stress resistance, decreased cancer incidence, and 
      increased neuronal function and neurogenesis. Several important signal 
      transduction pathways have been implicated in the regulation of the physiological 
      processes of CR leading to increased lifespan. One of these pathways includes the 
      Sirt1 pathway. Sirt1 deacetylates a large number of transcriptional factors and 
      cofactors involved in cell growth, differentiation, stress resistance, oxidative 
      damage, and metabolism. Recently, several studies report that resveratrol and 
      other compounds exogenously activate Sirt1 protein and improve the 
      obesity-associated pathology in mice. In this text, we introduce the recent 
      topics of CR research and discuss the anti-aging effects by CR.
FAU - Shimizu, Takahiko
AU  - Shimizu T
AD  - Research Team for Molecular Biomarkers, Tokyo Metropolitan Institute of 
      Gerontology.
FAU - Shirasawa, Takuji
AU  - Shirasawa T
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - *Caloric Restriction
MH  - Humans
MH  - Mice
EDAT- 2009/07/14 09:00
MHDA- 2009/09/04 06:00
CRDT- 2009/07/14 09:00
PHST- 2009/07/14 09:00 [entrez]
PHST- 2009/07/14 09:00 [pubmed]
PHST- 2009/09/04 06:00 [medline]
PST - ppublish
SO  - Nihon Rinsho. 2009 Jul;67(7):1366-71.