PMID- 19593889
OWN - NLM
STAT- MEDLINE
DCOM- 20090917
LR  - 20191027
IS  - 1473-5830 (Electronic)
IS  - 0954-6928 (Linking)
VI  - 20
IP  - 5
DP  - 2009 Aug
TI  - Interleukin-18: an independent predictor of cardiovascular events in patients 
      with acute coronary syndrome after 6 months of follow-up.
PG  - 327-331
AB  - BACKGROUND: Interleukin-18 (IL-18), a proinflammatory cytokine, has been 
      associated with atherogenesis and plaque rupture in acute coronary syndrome 
      (ACS). Recent studies suggest that IL-18 may have a long-term prognostic value. 
      The aim of this study was to evaluate the relationship between IL-18 levels and 
      major adverse cardiovascular events within 6 months of follow-up in post-ACS 
      patients. METHODS: One hundred and twelve consecutive patients admitted to a 
      university hospital with ACS were included in the study. IL-18 and C-reactive 
      protein were measured within the first 24 h of admission. Six months after 
      hospital discharge, the incidence of major adverse cardiovascular events 
      (cardiovascular death, new episode of ACS, and need for unplanned 
      revascularization) was assessed. RESULTS: Mean age of patients was 64 +/- 11 
      years, and 58 (52%) were male. During the 6 months of follow-up, 33 patients 
      (31.4%) experienced major adverse cardiovascular events. Median IL-18 serum 
      levels were higher among patients who had events than among those who did not: 
      271.7 pg/ml (interquartile range: 172.9-389.6) and 139.7 pg/ml (interquartile 
      range: 99.9-265.7), respectively (P < 0.01). In the Cox multivariate analysis, 
      after adjustment for clinical risk factors and serum troponin, elevated levels of 
      IL-18 were associated with higher incidence of events (hazard ratio: 2.5; 95% 
      confidence interval: 1.14-5.52; P = 0.023). In this population, C-reactive 
      protein was of borderline significance for events. CONCLUSION: Serum IL-18 levels 
      in ACS patients were independent predictors of long-term cardiovascular events. 
      These findings support the association between inflammation and prognosis of ACS 
      patients, as well as the clinical impact of this biomarker.
FAU - Furtado, Mariana Vargas
AU  - Furtado MV
AD  - Graduate Program in Cardiology of Federal University of Rio Grande do Sul, 
      Hospital de Clinicas de Porto Alegre, Porto Alegre RS 90035-903, Brazil. 
      mvargasfurtado@gmail.com
FAU - Rossini, Ana Paula Webber
AU  - Rossini AP
FAU - Campani, Raquel Barth
AU  - Campani RB
FAU - Meotti, Carolina
AU  - Meotti C
FAU - Segatto, Majorie
AU  - Segatto M
FAU - Vietta, Giovanna
AU  - Vietta G
FAU - Polanczyk, Carisi Anne
AU  - Polanczyk CA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Coron Artery Dis
JT  - Coronary artery disease
JID - 9011445
RN  - 0 (Biomarkers)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-18)
RN  - 0 (Troponin)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Acute Coronary Syndrome/complications/*immunology/mortality/therapy
MH  - Aged
MH  - Biomarkers/blood
MH  - C-Reactive Protein/metabolism
MH  - Cardiovascular Diseases/*immunology/mortality
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Inflammation Mediators/*blood
MH  - Interleukin-18/*blood
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Proportional Hazards Models
MH  - Recurrence
MH  - Risk Assessment
MH  - Time Factors
MH  - Treatment Outcome
MH  - Troponin/blood
EDAT- 2009/07/14 09:00
MHDA- 2009/09/18 06:00
CRDT- 2009/07/14 09:00
PHST- 2009/07/14 09:00 [entrez]
PHST- 2009/07/14 09:00 [pubmed]
PHST- 2009/09/18 06:00 [medline]
AID - 10.1097/mca.0b013e32832e5c73 [doi]
PST - ppublish
SO  - Coron Artery Dis. 2009 Aug;20(5):327-331. doi: 10.1097/mca.0b013e32832e5c73.