PMID- 19595004
OWN - NLM
STAT- MEDLINE
DCOM- 20100810
LR  - 20090714
IS  - 0529-5815 (Print)
IS  - 0529-5815 (Linking)
VI  - 47
IP  - 5
DP  - 2009 Mar 1
TI  - [Diagnosis and treatment of multiple endocrine neoplasia type 1 related 
      pancreatic endocrine tumors].
PG  - 329-32
AB  - OBJECTIVE: To summarize the experience on diagnosis and treatment of multiple 
      endocrine neoplasia type 1 (MEN-1) related pancreatic endocrine tumors (PET). 
      METHODS: From January 2004 to December 2007, there were 10 patients of MEN-1 
      related PET were treated in Shanghai Jiaotong University School of Medicine 
      Affiliated Ruijin Hospital. There were 2 males and 8 females, aged from 11- to 
      49-years-old. They were diagnosed by laboratory tests, imaging examinations and 
      genes sequencing. Drug therapy, surgery and follow-up were applied on the 
      patients. RESULTS: There were 9 patients having insulinomas including 2 cases of 
      multiple insulinomas and 1 case presenting an insulinoma, multiple nonfunctional 
      PET and malignant duodenum gastrinoma with liver metastasis. The other patient 
      was diagnosed as glucagonoma clinically. Five cases had family history and MEN-1 
      gene mutation was detected in 9 patients. Seven patients accepted nine 
      operations. Twelve insulinomas, four nonfunctional PET and one duodenum 
      gastrinoma were found in the operations. All patients were followed up from 1 
      month to 11 years, and 9 patients with good conditions and 1 patient died. 
      CONCLUSIONS: Well recognizing PET and MEN-1, early diagnosing MEN-1 related PET, 
      appropriately surgical intervention will prove patients' life quality and will 
      help for prolonging patients' survival time.
FAU - Yang, Jun
AU  - Yang J
AD  - Department of Surgery, Shanghai Jiaotong University School of Medicine Affiliated 
      Ruijin Hospital, Shanghai 200025, China.
FAU - Zhou, Guang-wen
AU  - Zhou GW
FAU - Chen, Xi
AU  - Chen X
FAU - Wei, Yao
AU  - Wei Y
FAU - Peng, Cheng-hong
AU  - Peng CH
FAU - Ning, Guang
AU  - Ning G
FAU - Li, Hong-wei
AU  - Li HW
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Wai Ke Za Zhi
JT  - Zhonghua wai ke za zhi [Chinese journal of surgery]
JID - 0153611
SB  - IM
MH  - Adult
MH  - Child
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*diagnosis/*surgery
MH  - Pancreatic Neoplasms/*diagnosis/*surgery
MH  - Retrospective Studies
EDAT- 2009/07/15 09:00
MHDA- 2010/08/11 06:00
CRDT- 2009/07/15 09:00
PHST- 2009/07/15 09:00 [entrez]
PHST- 2009/07/15 09:00 [pubmed]
PHST- 2010/08/11 06:00 [medline]
PST - ppublish
SO  - Zhonghua Wai Ke Za Zhi. 2009 Mar 1;47(5):329-32.