PMID- 19595005
OWN - NLM
STAT- MEDLINE
DCOM- 20100810
LR  - 20090714
IS  - 0529-5815 (Print)
IS  - 0529-5815 (Linking)
VI  - 47
IP  - 5
DP  - 2009 Mar 1
TI  - [Clinical experience in diagnosis and treatment of glucagonoma].
PG  - 333-6
AB  - OBJECTIVE: To study the diagnosis and treatment of glucagonoma. METHODS: A 
      retrospective review of glucagonoma cases was committed between June 1993 and 
      July 2008 in Peking Union Medical College Hospital. It was measured by sex, age, 
      misdiagnosis, clinical symptoms, laboratory data, imaging studies, diagnosis, 
      treatment procedures and so on. RESULTS: The tumors of eleven cases were found in 
      the tail, and one case was in the head of the pancreas at the same time. Ten had 
      solitary lesion, one had multiple lesions. The average diameter of the lesions 
      was 3.9 cm. Nine patients had the metastasis out of pancreas and all of them had 
      the liver metastasis. One case was a member of multiple endocrine neoplasia type 
      1 (MEN-1) syndromes. Eight patients being treated with operation had the detailed 
      pathological reports. The glucagon was detected by immunohistochemistry and was 
      positive in five patients. Six patients were pathologically malignant. Multimodal 
      treatments included tumor resection, chemoembolization, treated with somatostatin 
      analogues and (or) radionuclides and so on were applied to all patients. 
      CONCLUSIONS: Glucagonoma is a rare pancreatic endocrine tumor. Radical tumor 
      surgery is used as the first choice. Multimodal approach may improve the 
      prognosis.
FAU - Liu, Wen-jing
AU  - Liu WJ
AD  - Department of Surgery, Peking Union Medical College Hospital, Chinese Academy of 
      Medical Science, Beijing 100730, China.
FAU - Zhao, Yu-pei
AU  - Zhao YP
FAU - Zhang, Tai-ping
AU  - Zhang TP
FAU - Liao, Quan
AU  - Liao Q
FAU - Cong, Lin
AU  - Cong L
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Wai Ke Za Zhi
JT  - Zhonghua wai ke za zhi [Chinese journal of surgery]
JID - 0153611
SB  - IM
MH  - Adult
MH  - Female
MH  - Follow-Up Studies
MH  - Glucagonoma/*diagnosis/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pancreatic Neoplasms/*diagnosis/*therapy
MH  - Prognosis
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 2009/07/15 09:00
MHDA- 2010/08/11 06:00
CRDT- 2009/07/15 09:00
PHST- 2009/07/15 09:00 [entrez]
PHST- 2009/07/15 09:00 [pubmed]
PHST- 2010/08/11 06:00 [medline]
PST - ppublish
SO  - Zhonghua Wai Ke Za Zhi. 2009 Mar 1;47(5):333-6.