PMID- 19595056
OWN - NLM
STAT- MEDLINE
DCOM- 20091110
LR  - 20090714
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 89
IP  - 10
DP  - 2009 Mar 17
TI  - [Characteristics of glycometabolism in the first-degree relatives of type 2 
      diabetes patients assessed by continuous glucose monitoring system].
PG  - 655-8
AB  - OBJECTIVE: To investigate the characteristics of glycemic stability in the 
      first-degree relatives of type 2 diabetes mellitus (T2DM) patients by continuous 
      glucose monitoring system (CGMS). METHODS: Twenty-two first-degree relatives 
      (FDRs) of T2DM patients and 28 age and gender-matched controls underwent CGMS to 
      obtain the mean blood glucose (MBG), standard deviation of MBG (SDBG), mean of 
      daily differences (MODD), and mean amplitude of glycemic excursions (MAGE). Oral 
      glucose tolerance test (OGTT) was conducted. Blood glucose, serum lipids, and 
      serum insulin were assayed. The insulin sensitivity and resistance was assessed 
      by HOMA-beta, HOMA-IR, DeltaI(30)/DeltaG(30) and modified beta cell function 
      index (MBCI). RESULTS: There were no significant differences between the FDR and 
      control groups in the levels of plasma glucose in OGTT, MBG, SDBG, and MOOD. 
      However, the MAGE level of the FDR group was (2.3 +/- 0.5) mmol/L, significantly 
      higher than that of the control group [(2.0 +/- 0.6) mmol/L, P < 0.05]. The MBCI 
      level of the FDR group was 17.6 (16.9 - 50.0), significantly lower than that of 
      the control group [36.0 (15.7 - 59.6), P < 0.05]. There were no significant 
      differences in the serum lipids profile, body fat distribution, HOMA-beta, 
      HOMA-IR, and DeltaI(30)/DeltaG(30) between these two groups. CONCLUSION: The 
      excursion of blood glucose is greater in the FDRs of T2DM patients. CGMS is more 
      sensitive to discover such change than OGTT.
FAU - Chen, Li-Li
AU  - Chen LL
AD  - Department of Endocrinology, Second Affiliated Hospital of Harbin Medical 
      University, Harbin 150086, China.
FAU - Li, Qiang
AU  - Li Q
FAU - Wang, Wei
AU  - Wang W
FAU - Cui, Can
AU  - Cui C
FAU - Yu, Ping
AU  - Yu P
FAU - Bao, Li-Li
AU  - Bao LL
FAU - Wang, Jun
AU  - Wang J
FAU - Zhou, Jian
AU  - Zhou J
FAU - Bao, Yu-Qian
AU  - Bao YQ
FAU - Jia, Wei-Ping
AU  - Jia WP
FAU - Sun, Yu-Qian
AU  - Sun YQ
FAU - Zhang, Jin-Chao
AU  - Zhang JC
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adult
MH  - Blood Glucose/*metabolism
MH  - Blood Glucose Self-Monitoring
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Family
MH  - Female
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Young Adult
EDAT- 2009/07/15 09:00
MHDA- 2009/11/11 06:00
CRDT- 2009/07/15 09:00
PHST- 2009/07/15 09:00 [entrez]
PHST- 2009/07/15 09:00 [pubmed]
PHST- 2009/11/11 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2009 Mar 17;89(10):655-8.