PMID- 19595059
OWN - NLM
STAT- MEDLINE
DCOM- 20091110
LR  - 20090714
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 89
IP  - 10
DP  - 2009 Mar 17
TI  - [Characteristics of glycemic excursion in different subtypes of impaired glucose 
      intolerance].
PG  - 669-72
AB  - OBJECTIVE: To investigate the characteristics of glycemic excursion of different 
      subtypes of glucose tolerance. METHODS: Assessed by oral glucose tolerance test 
      (OGTT) repeated twice, 81 individuals were divided into 4 groups: normal glucose 
      tolerance (NGT, n = 18), isolated impaired fasting glycemia (IFG, n = 12), 
      isolated impaired glucose tolerance (IGT, n = 19), combined IFG/IGT (n = 11), and 
      newly diagnosed type 2 diabetes mellitus (T2DM, n = 21). And then continuous 
      glucose monitoring system (CGMS) was used for 72 hours to monitor the blood 
      glucose (BG) level before drug intervention. RESULTS: (1) The levels of largest 
      amplitude of glycemic excursions (LAGE), mean blood glucose (MBG), and standard 
      deviation of mean level of blood glucose fluctuation (SDBG) increased gradually 
      with the deterioration of glucose tolerance. The mean amplitude of glucose 
      excursion (MAGE) readout of the IGT group was (3.2 +/- 1.2) mmol/L, significantly 
      higher than that of the NGT group [(1.6 +/- 0.5) mmol/L, P < 0.05], and 
      significantly lower than that of the T2DM group [(5.2 +/- 1.9) mmol/L, P < 0.05]. 
      The level of frequency of glucose excursion (FGE) decreased along with the 
      decrease of glucose tolerance: NGT group [(6.1 +/- 3.4)] > IGT/IFG group [(5.5 
      +/- 2.5)] > T2DM group [(4.8 +/- 1.8)]. Among the three components of IGR, the 
      IGT group showed highest MAGE (3.2 +/- 1.2) mmol/L and lowest FGE level (4.9 +/- 
      1.8). (2) The level of absolute mean of daily difference (MODD) increased in the 
      following order: NGT group [(0.8 +/- 0.3) mmol/L], IGT group [(1.1 +/- 0.4) 
      mmol/L], IFG/IGT group [(1.2 +/- 0.4) mmol/L], and T2DM group [(2.0 +/- 1.0) 
      mmol/L] (all P < 0.05). (3) The fasting glucose level deteriorated the most 
      rapidly in the IFG group, while it reached the highest postprandial peak in the 
      IFG/IGT group. The blood glucose curve increased along the order of NGT, I-IGT, 
      IFG/IGT, IFG, and T2DM. (4) When the level of glycosylated hemoglobin (HbA1c) 
      level was less than 7%, the fasting phase of curve virtually coincided with each 
      other among individual groups with different HbA1c levels; however, the 
      postprandial peak separated slightly. When the HbA1C level was between 7.0% and 
      7.9%, the postprandial peaks of individual groups with different HbA1c levels 
      dispersed markedly. When the HbA1c level was higher than 8%, the fasting blood 
      glucose curve moved upwards significantly with increasing postprandial excursion. 
      CONCLUSION: (1) With the deterioration of glucose regulation, the intraday and 
      day-to-day blood glucose excursions become increasingly fluctuant. (2) The 
      amplitude of glycemic excursion is lower in the NGT group than in the T2DM group, 
      however, the frequency of glycemic excursion is higher in the NGT subject than in 
      the T2DM subjects. The glucose excursion profile of the IGR subjects is between 
      the NGR and T2DM subjects. (3) The characteristics of glucose excursion of the 
      IGT group are similar to those of the T2DM group, and the characteristics of the 
      IFG group are similar to those of the NGT group. (4) The loss of postprandial 
      glycemic control precedes evident deterioration in fasting phase of IGR.
FAU - Kang, Yi
AU  - Kang Y
AD  - Department of Endocrinology, General Hospital of Chinese People's Liberation 
      Army, Beijing 100853, China.
FAU - Lu, Ju-Ming
AU  - Lu JM
FAU - Sun, Jing-Fang
AU  - Sun JF
FAU - Li, Chun-Lin
AU  - Li CL
FAU - Wang, Xian-Ling
AU  - Wang XL
FAU - Zhang, Xiao-Qun
AU  - Zhang XQ
FAU - Lu, Zhao-Hui
AU  - Lu ZH
FAU - Dou, Jing-Tao
AU  - Dou JT
FAU - Mu, Yi-Ming
AU  - Mu YM
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Glucose/*metabolism
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Follow-Up Studies
MH  - Glucose Intolerance/*metabolism
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 2009/07/15 09:00
MHDA- 2009/11/11 06:00
CRDT- 2009/07/15 09:00
PHST- 2009/07/15 09:00 [entrez]
PHST- 2009/07/15 09:00 [pubmed]
PHST- 2009/11/11 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2009 Mar 17;89(10):669-72.