PMID- 19595264
OWN - NLM
STAT- MEDLINE
DCOM- 20091208
LR  - 20110913
IS  - 1330-027X (Print)
IS  - 1330-027X (Linking)
VI  - 17
IP  - 2
DP  - 2009
TI  - Cutaneous morphometric parameters of young FVB/N mice sustained in aged mice and 
      in calorically restricted transgenic alphaMUPA mice.
PG  - 99-102
AB  - Caloric restriction (CR) extends the lifespan of diverse animal species and is 
      currently the only therapeutic intervention known to attenuate aging and increase 
      longevity in laboratory animals. The effect of CR on intrinsic skin aging is not 
      well understood. To study this issue, we took advantage of transgenic alphaMUPA 
      mice that spontaneously eat less (20-30%) when fed ad libitum and live longer 
      compared to their wild type (WT) FVB/N control mice. Herein we determined 
      morphometric skin parameters in young (6-7 months) and aged (17-18 months) 
      alphaMUPA and WT mice. In addition, we transplanted skin grafts excised from the 
      aged or young alphaMUPA and WT mice into both types of young mice, to test 
      whether the systemic environments of alphaMUPA and WT mice could affect the 
      grafts differently. The results have shown that the mean epidermal thickness, 
      number of hair follicles and number of dermal blood vessels were similar in all 
      four groups regardless of age or mouse type. In addition, the post-graft 
      specimens of all four groups exhibited increase in all parameters measured, in 
      particular a remarkable 6-7 fold increase in epidermal thickness. However, no 
      significant differences were detected in the post-graft samples between the four 
      experimental groups. Our findings indicate that, at least in FVB/N mice, 
      parameters measured in normal or grafted skin depend primarily on the intrinsic 
      cutaneous capacity rather than on circulating factors as determined by age or 
      reduced calories.
FAU - Matanis, Ellias
AU  - Matanis E
AD  - Skin Research Laboratory, B. Rappaport Faculty of Medicine, Technion - Israel 
      Institute of Technology, P.O.B. 9649, Bat-Galim, Haifa, 31096 Israel.
FAU - Munder, Hakim
AU  - Munder H
FAU - Ullmann, Yehuda
AU  - Ullmann Y
FAU - Miskin, Ruth
AU  - Miskin R
FAU - Gilhar, Amos
AU  - Gilhar A
LA  - eng
PT  - Journal Article
PL  - Croatia
TA  - Acta Dermatovenerol Croat
JT  - Acta dermatovenerologica Croatica : ADC
JID - 9433781
RN  - EC 3.4.21.73 (Urokinase-Type Plasminogen Activator)
SB  - IM
MH  - Aging
MH  - Animals
MH  - Caloric Restriction
MH  - Graft Survival
MH  - Mice
MH  - Mice, Transgenic
MH  - Models, Animal
MH  - Skin/blood supply
MH  - Skin Aging/*physiology
MH  - Skin Transplantation
MH  - Urokinase-Type Plasminogen Activator/genetics
EDAT- 2009/07/15 09:00
MHDA- 2009/12/16 06:00
CRDT- 2009/07/15 09:00
PHST- 2009/07/15 09:00 [entrez]
PHST- 2009/07/15 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
PST - ppublish
SO  - Acta Dermatovenerol Croat. 2009;17(2):99-102.