PMID- 19595522
OWN - NLM
STAT- MEDLINE
DCOM- 20100401
LR  - 20091020
IS  - 1873-2542 (Electronic)
IS  - 0378-1135 (Linking)
VI  - 139
IP  - 3-4
DP  - 2009 Nov 18
TI  - Vaccine efficacy and immune response to swine influenza virus challenge in pigs 
      infected with porcine reproductive and respiratory syndrome virus at the time of 
      SIV vaccination.
PG  - 235-44
LID - 10.1016/j.vetmic.2009.06.003 [doi]
AB  - The objective of this study was to assess the effect of concurrent infection with 
      porcine reproductive and respiratory syndrome virus (PRRSV) on the efficacy of an 
      inactivated swine influenza virus (SIV) vaccine. Eight groups of pigs were 
      infected with a virulent PRRSV isolate either between the two SIV vaccines or at 
      the time of SIV challenge. Control groups included SIV vaccination without PRRSV 
      and pigs infected with SIV and/or PRRSV. Pigs infected with PRRSV during 
      vaccination showed increased levels of macroscopic and microscopic lesions 
      compared to pigs vaccinated against and challenged with only SIV indicating 
      decreased SIV vaccine efficacy. In addition, pigs vaccinated in the presence of 
      PRRSV showed increased clinical disease and shedding of SIV during the acute 
      phase of SIV infection. No alterations in the systemic or local antibody response 
      to either SIV vaccination or challenge were observed. These findings demonstrate 
      that PRRSV infection has a significant impact on SIV vaccine efficacy that may be 
      important for disease control.
FAU - Kitikoon, Pravina
AU  - Kitikoon P
AD  - Department of Veterinary Microbiology and Preventive Medicine, College of 
      Veterinary Medicine, P.O. Box 3020, Iowa State University, Ames, IA 50010, USA.
FAU - Vincent, Amy L
AU  - Vincent AL
FAU - Jones, Katherine R
AU  - Jones KR
FAU - Nilubol, Dachrit
AU  - Nilubol D
FAU - Yu, Shan
AU  - Yu S
FAU - Janke, Bruce H
AU  - Janke BH
FAU - Thacker, Brad J
AU  - Thacker BJ
FAU - Thacker, Eileen L
AU  - Thacker EL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090611
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
RN  - 0 (Antibodies, Viral)
RN  - 0 (Influenza Vaccines)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/analysis
MH  - Influenza A Virus, H1N1 Subtype/*immunology
MH  - Influenza A Virus, H3N2 Subtype/*immunology
MH  - Influenza Vaccines/*immunology
MH  - Orthomyxoviridae Infections/immunology/prevention & control/*veterinary
MH  - Porcine Reproductive and Respiratory Syndrome/*immunology
MH  - *Sus scrofa
MH  - Swine Diseases/immunology/*prevention & control
EDAT- 2009/07/15 09:00
MHDA- 2010/04/02 06:00
CRDT- 2009/07/15 09:00
PHST- 2008/12/18 00:00 [received]
PHST- 2009/05/28 00:00 [revised]
PHST- 2009/06/03 00:00 [accepted]
PHST- 2009/07/15 09:00 [entrez]
PHST- 2009/07/15 09:00 [pubmed]
PHST- 2010/04/02 06:00 [medline]
AID - S0378-1135(09)00287-9 [pii]
AID - 10.1016/j.vetmic.2009.06.003 [doi]
PST - ppublish
SO  - Vet Microbiol. 2009 Nov 18;139(3-4):235-44. doi: 10.1016/j.vetmic.2009.06.003. 
      Epub 2009 Jun 11.