PMID- 19596259
OWN - NLM
STAT- MEDLINE
DCOM- 20090729
LR  - 20221207
IS  - 1873-4456 (Electronic)
IS  - 0165-4608 (Linking)
VI  - 192
IP  - 2
DP  - 2009 Jul 15
TI  - Trisomy 8 in two newly diagnosed Chinese patients with chronic lymphocytic 
      leukemia.
PG  - 79-81
LID - 10.1016/j.cancergencyto.2009.04.007 [doi]
AB  - Chronic lymphocytic leukemia (CLL) is one of the most common lymphoid 
      malignancies in Western countries, but is infrequent in Asian populations. To 
      verify the incidence of trisomy 8 in Chinese patients with CLL, fluorescence in 
      situ hybridization (FISH) was used in 140 CLL patients after routine chromosome 
      analysis. Only two patients (1.4%) were found with trisomy 8, and the number of 
      trisomy 8 cells was 8 and 10%, respectively. No other aberrations by "panel" 
      probe FISH were found in these two patients. The chromosome karyotypes of two 
      patients were 47,XY,+8[2]/49,XY,+14,+20,+21[2]/46,XY[16] and 
      47,XX,+8[2]/46,XX[18], respectively. Neither of the patients' present signs of 
      myelodysplastic or myeloproliferative disorder appeared on the bone marrow 
      aspirates and peripheral blood smear. Our study demonstrates that trisomy 8 is 
      rare in CLL, and its role in prognosis of CLL remains unknown.
FAU - Xu, Wei
AU  - Xu W
AD  - Department of Hematology, the First Affiliated Hospital of Nanjing Medical 
      University, Jiangsu Province Hospital, 300 Guangzhou Road, Nanjing, China.
FAU - Cao, Xin
AU  - Cao X
FAU - Liu, Qiong
AU  - Liu Q
FAU - Fan, Lei
AU  - Fan L
FAU - Miao, Kou-Rong
AU  - Miao KR
FAU - Qiu, Hai-Rong
AU  - Qiu HR
FAU - Zhu, Dan-Xia
AU  - Zhu DX
FAU - Qiu, Hong-Xia
AU  - Qiu HX
FAU - Li, Jian-Yong
AU  - Li JY
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People/*genetics
MH  - China
MH  - Chromosomes, Human, Pair 8/*genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*diagnosis/*genetics
MH  - Male
MH  - Middle Aged
MH  - Trisomy/*diagnosis/*genetics
EDAT- 2009/07/15 09:00
MHDA- 2009/07/30 09:00
CRDT- 2009/07/15 09:00
PHST- 2009/01/20 00:00 [received]
PHST- 2009/04/06 00:00 [accepted]
PHST- 2009/07/15 09:00 [entrez]
PHST- 2009/07/15 09:00 [pubmed]
PHST- 2009/07/30 09:00 [medline]
AID - S0165-4608(09)00226-X [pii]
AID - 10.1016/j.cancergencyto.2009.04.007 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2009 Jul 15;192(2):79-81. doi: 
      10.1016/j.cancergencyto.2009.04.007.