PMID- 19597844
OWN - NLM
STAT- MEDLINE
DCOM- 20100106
LR  - 20221207
IS  - 1432-1203 (Electronic)
IS  - 0340-6717 (Print)
IS  - 0340-6717 (Linking)
VI  - 126
IP  - 5
DP  - 2009 Nov
TI  - Clear and independent associations of several HLA-DRB1 alleles with differential 
      antibody responses to hepatitis B vaccination in youth.
PG  - 685-96
LID - 10.1007/s00439-009-0720-z [doi]
AB  - To confirm and refine associations of human leukocyte antigen (HLA) genotypes 
      with variable antibody (Ab) responses to hepatitis B vaccination, we have 
      analyzed 255 HIV-1 seropositive (HIV(+)) youth and 80 HIV-1 seronegatives 
      (HIV(-)) enrolled into prospective studies. In univariate analyses that focused 
      on HLA-DRB1, -DQA1, and -DQB1 alleles and haplotypes, the DRB1*03 allele group 
      and DRB1*0701 were negatively associated with the responder phenotype (serum Ab 
      concentration > or = 10 mIU/mL) (P = 0.026 and 0.043, respectively). 
      Collectively, DRB1*03 and DRB1*0701 were found in 42 (53.8%) out of 78 
      non-responders (serum Ab <10 mIU/mL), 65 (40.6%) out of 160 medium responders 
      (serum Ab 10-1,000 mIU/mL), and 27 (27.8%) out of 97 high responders (serum Ab 
      >1,000 mIU/mL) (P < 0.001 for trend). Meanwhile, DRB1*08 was positively 
      associated with the responder phenotype (P = 0.010), mostly due to DRB1*0804 (P = 
      0.008). These immunogenetic relationships were all independent of non-genetic 
      factors, including HIV-1 infection status and immunodeficiency. Alternative 
      analyses confined to HIV(+) youth or Hispanic youth led to similar findings. In 
      contrast, analyses of more than 80 non-coding, single nucleotide polymorphisms 
      within and beyond the three HLA class II genes revealed no clear associations. 
      Overall, several HLA-DRB1 alleles were major predictors of differential Ab 
      responses to hepatitis B vaccination in youth, suggesting that T-helper 
      cell-dependent pathways mediated through HLA class II antigen presentation are 
      critical to effective immune response to recombinant vaccines.
FAU - Li, Yufeng
AU  - Li Y
AD  - Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 
      35294, USA.
FAU - Ni, Rong
AU  - Ni R
FAU - Song, Wei
AU  - Song W
FAU - Shao, Wenshuo
AU  - Shao W
FAU - Shrestha, Sadeep
AU  - Shrestha S
FAU - Ahmad, Sushma
AU  - Ahmad S
FAU - Cunningham, Coleen K
AU  - Cunningham CK
FAU - Flynn, Patricia M
AU  - Flynn PM
FAU - Kapogiannis, Bill G
AU  - Kapogiannis BG
FAU - Wilson, Craig M
AU  - Wilson CM
FAU - Tang, Jianming
AU  - Tang J
LA  - eng
GR  - K02 AI076123/AI/NIAID NIH HHS/United States
GR  - U01 HD040474/HD/NICHD NIH HHS/United States
GR  - U01 HD040533/HD/NICHD NIH HHS/United States
PT  - Journal Article
DEP - 20090714
PL  - Germany
TA  - Hum Genet
JT  - Human genetics
JID - 7613873
RN  - 0 (HLA-D Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Hepatitis B Vaccines)
SB  - IM
MH  - Adolescent
MH  - Analysis of Variance
MH  - Antibody Formation/*genetics
MH  - Black People/genetics
MH  - Brazil
MH  - Female
MH  - Genetic Variation
MH  - HIV Seronegativity
MH  - HLA-D Antigens/genetics
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes/genetics
MH  - Hepatitis B Vaccines/immunology/*therapeutic use
MH  - Hispanic or Latino/genetics
MH  - Humans
MH  - Male
MH  - Multivariate Analysis
MH  - Polymorphism, Single Nucleotide
MH  - South Africa
MH  - United States
MH  - White People/genetics
MH  - Young Adult
PMC - PMC2771141
EDAT- 2009/07/15 09:00
MHDA- 2010/01/07 06:00
PMCR- 2009/07/14
CRDT- 2009/07/15 09:00
PHST- 2009/05/28 00:00 [received]
PHST- 2009/07/05 00:00 [accepted]
PHST- 2009/07/15 09:00 [entrez]
PHST- 2009/07/15 09:00 [pubmed]
PHST- 2010/01/07 06:00 [medline]
PHST- 2009/07/14 00:00 [pmc-release]
AID - 720 [pii]
AID - 10.1007/s00439-009-0720-z [doi]
PST - ppublish
SO  - Hum Genet. 2009 Nov;126(5):685-96. doi: 10.1007/s00439-009-0720-z. Epub 2009 Jul 
      14.