PMID- 19604073
OWN - NLM
STAT- MEDLINE
DCOM- 20091124
LR  - 20191210
IS  - 1473-4877 (Electronic)
IS  - 0300-7995 (Linking)
VI  - 25
IP  - 9
DP  - 2009 Sep
TI  - Clinical and resource-use outcomes of risperidone long-acting injection in recent 
      and long-term diagnosed schizophrenia patients: results from a multinational 
      electronic registry.
PG  - 2197-206
LID - 10.1185/03007990903149306 [doi]
AB  - BACKGROUND: Non-adherence to pharmacological treatment leading to frequent 
      relapses and rehospitalizations is a major issue of concern among schizophrenia 
      patients, especially those who are recently diagnosed. Risperidone long-acting 
      injection (RLAI) has been shown to be efficacious, improve compliance, and 
      increase long-term retention rate on therapy. OBJECTIVE: To determine clinical 
      outcomes and hospitalizations before and after the initiation of RLAI among 
      schizophrenia patients with recent (< or =2 years) diagnosis relative to those 
      who had long-term (> 2 years) diagnosis. RESEARCH DESIGN AND METHODS: The 
      electronic Schizophrenia Treatment Adherence Registry (e-STAR) is an 
      observational study of patients with schizophrenia who start treatment with RLAI. 
      Data were recorded at baseline, retrospectively for the 12 months prior to 
      baseline, and prospectively every 3 months for 24 months. Data on patients with a 
      defined length of diagnosis were pooled from eight countries. MAIN OUTCOME 
      MEASURES: Clinical Global Impression of Illness Severity (CGI-S), Global 
      Assessment of Functioning (GAF) scores, and hospitalization data were key 
      outcomes. RESULTS: The magnitude of improvement in CGI-S scores was greater in 
      the recent versus long-term diagnosis group [Delta -1.48 vs. Delta -0.95 (12 
      months); Delta -1.6 vs. Delta -1.09 (24 months)]. There were parallel 
      improvements in GAF scores [Delta 19.4 vs. Delta 13.7 (12 months); Delta 22.3 vs. 
      Delta 16.8 (24 months)]. The decline in the proportion of patients hospitalized 
      from the retrospective to the prospective period was greater in the recent versus 
      long-term diagnosis group (Delta -36.0 vs. Delta -19%, respectively) at 12 
      months. This was also true for the number of hospital stays (Delta -0.6 vs. Delta 
      -0.3, respectively) and length of stay (days) (Delta -20.9 vs. Delta -6.9, 
      respectively) at 12 months. Common adverse events in both groups included 
      psychiatric, gastrointestinal, musculoskeletal and reproductive system and breast 
      disorders. CONCLUSIONS: Treatment with RLAI is associated with improved outcomes 
      in recently diagnosed and chronic patients. However, the magnitude of improvement 
      was higher in recently diagnosed patients.
FAU - Olivares, J M
AU  - Olivares JM
AD  - Servicio de Psiquiatria, Hospital Meixoeiro, Complejo Hospitalario Universitario 
      de Vigo, Vigo, Spain. jose.manuel.olivares@gmail.com
FAU - Peuskens, J
AU  - Peuskens J
FAU - Pecenak, J
AU  - Pecenak J
FAU - Resseler, S
AU  - Resseler S
FAU - Jacobs, A
AU  - Jacobs A
FAU - Akhras, K S
AU  - Akhras KS
CN  - e-STAR Study Group
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Curr Med Res Opin
JT  - Current medical research and opinion
JID - 0351014
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Delayed-Action Preparations)
RN  - L6UH7ZF8HC (Risperidone)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Antipsychotic Agents/administration & dosage/adverse effects
MH  - Delayed-Action Preparations
MH  - Electronic Data Processing
MH  - Female
MH  - Follow-Up Studies
MH  - Health Resources/*statistics & numerical data
MH  - Humans
MH  - Internationality
MH  - Male
MH  - Middle Aged
MH  - Registries
MH  - Retrospective Studies
MH  - Risperidone/*administration & dosage/adverse effects
MH  - Schizophrenia/*drug therapy/epidemiology
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2009/07/17 09:00
MHDA- 2009/12/16 06:00
CRDT- 2009/07/17 09:00
PHST- 2009/07/17 09:00 [entrez]
PHST- 2009/07/17 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
AID - 10.1185/03007990903149306 [doi]
PST - ppublish
SO  - Curr Med Res Opin. 2009 Sep;25(9):2197-206. doi: 10.1185/03007990903149306.