PMID- 19607684
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20091214
LR  - 20211020
IS  - 1742-6405 (Electronic)
IS  - 1742-6405 (Linking)
VI  - 6
DP  - 2009 Jul 16
TI  - Polychromatic immunophenotypic characterization of T cell profiles among 
      HIV-infected patients experiencing immune reconstitution inflammatory syndrome 
      (IRIS).
PG  - 16
LID - 10.1186/1742-6405-6-16 [doi]
AB  - OBJECTIVE: To immunophenotype CD4+ and CD8+ T cell sub-populations in 
      HIV-associated immune reconstitution inflammatory syndrome (IRIS). DESIGN: Nested 
      case-control immunological study. METHODS: ART-naive HIV-infected patients were 
      prospectively observed for IRIS during the first 6 months of ART. Twenty-two IRIS 
      cases and 22 ART-duration matched controls were sampled for T cell 
      immunophenotyping. RESULTS: IRIS cases demonstrated significantly lower CD4 cell 
      counts compared to controls (baseline: 79 versus 142, p = 0.02; enrollment: 183 
      versus 263, p = 0.05, respectively) with no differences in HIV RNA levels. Within 
      CD4+T cells, cases exhibited more of an effector memory phenotype compared to 
      controls (40.8 versus 27.0%, p = 0.20), while controls trended towards a central 
      memory phenotype (43.8 versus 30.8%, p = 0.07). Within CD8+ T cells, controls 
      exhibited more central memory (13.9 versus 7.81%, p = 0.01, respectively) and 
      effector (13.2 versus 8.8%, p = 0.04, respectively) phenotypes compared to cases, 
      whereas cases demonstrated more terminal effectors than controls (28.8 versus 
      15.1%, p = 0.05). Cases demonstrated increased activation of CD8+ T cell effector 
      memory, terminal effector, and effector subsets than controls (p = 0.04, 0.02, 
      and 0.02, respectively). CONCLUSION: CD4+ and CD8+ T cell subset maturational 
      phenotypes were heterogeneous among IRIS cases and controls. However, IRIS cases 
      demonstrated significant increases in activation of CD8+ T cell effector 
      subpopulations.
FAU - Murdoch, David M
AU  - Murdoch DM
AD  - Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, 
      Durham, North Carolina, USA. dmurdoch@email.unc.edu
FAU - Suchard, Melinda S
AU  - Suchard MS
FAU - Venter, Willem D F
AU  - Venter WD
FAU - Mhlangu, Patrick
AU  - Mhlangu P
FAU - Ottinger, Janet S
AU  - Ottinger JS
FAU - Feldman, Charles
AU  - Feldman C
FAU - Van Rie, Annelies
AU  - Van Rie A
FAU - Glencross, Deborah K
AU  - Glencross DK
FAU - Stevens, Wendy S
AU  - Stevens WS
FAU - Weinhold, Kent J
AU  - Weinhold KJ
LA  - eng
GR  - D71 TW006906/TW/FIC NIH HHS/United States
GR  - K01 TW008005/TW/FIC NIH HHS/United States
GR  - P30 AI050410/AI/NIAID NIH HHS/United States
GR  - P30 AI064518/AI/NIAID NIH HHS/United States
PT  - Journal Article
DEP - 20090716
PL  - England
TA  - AIDS Res Ther
JT  - AIDS research and therapy
JID - 101237921
PMC - PMC2723132
EDAT- 2009/07/18 09:00
MHDA- 2009/07/18 09:01
PMCR- 2009/07/16
CRDT- 2009/07/18 09:00
PHST- 2009/03/03 00:00 [received]
PHST- 2009/07/16 00:00 [accepted]
PHST- 2009/07/18 09:00 [entrez]
PHST- 2009/07/18 09:00 [pubmed]
PHST- 2009/07/18 09:01 [medline]
PHST- 2009/07/16 00:00 [pmc-release]
AID - 1742-6405-6-16 [pii]
AID - 10.1186/1742-6405-6-16 [doi]
PST - epublish
SO  - AIDS Res Ther. 2009 Jul 16;6:16. doi: 10.1186/1742-6405-6-16.