PMID- 19607928
OWN - NLM
STAT- MEDLINE
DCOM- 20091104
LR  - 20211028
IS  - 1095-9572 (Electronic)
IS  - 1053-8119 (Print)
IS  - 1053-8119 (Linking)
VI  - 48
IP  - 3
DP  - 2009 Nov 15
TI  - Static and dynamic characteristics of cerebral blood flow during the resting 
      state.
PG  - 515-24
LID - 10.1016/j.neuroimage.2009.07.006 [doi]
AB  - In this study, the static and dynamic characteristics of cerebral blood flow 
      (CBF) in the resting state were investigated using an arterial spin labeling 
      (ASL) perfusion imaging technique. Consistent with previous PET results, static 
      CBF measured by ASL was significantly higher in the posterior cingulate cortex 
      (PCC), thalamus, insula/superior temporal gyrus (STG) and medial prefrontal 
      cortex (MPFC) than the average CBF of the brain. The dynamic measurement of CBF 
      fluctuations showed high correlation (functional connectivity) between components 
      in the default mode network. These brain regions also had high local temporal 
      synchrony and high fluctuation amplitude, as measured by regional homogeneity 
      (ReHo) and amplitude of low-frequency fluctuation (ALFF) analyses. The spatial 
      pattern of the static CBF correlated well with that of the dynamic indices. The 
      high static and dynamic activities in the PCC, MPFC, insula/STG and thalamus 
      suggest that these regions play a vital role in maintaining and facilitating 
      fundamental brain functions.
FAU - Zou, Qihong
AU  - Zou Q
AD  - Neuroimaging Research Branch, National Institute on Drug Abuse, National 
      Institutes of Health, 251 Bayview Blvd., Suite 200, Baltimore, MD 21224, USA.
FAU - Wu, Changwei W
AU  - Wu CW
FAU - Stein, Elliot A
AU  - Stein EA
FAU - Zang, Yufeng
AU  - Zang Y
FAU - Yang, Yihong
AU  - Yang Y
LA  - eng
GR  - Z01 DA000469-04/ImNIH/Intramural NIH HHS/United States
GR  - Z99 DA999999/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20090714
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
RN  - 0 (Spin Labels)
SB  - IM
MH  - Adult
MH  - Brain/*blood supply/*physiology
MH  - Brain Mapping
MH  - Cerebrovascular Circulation/*physiology
MH  - Female
MH  - Humans
MH  - Kinetics
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Perfusion Imaging
MH  - Rest/*physiology
MH  - Spin Labels
PMC - PMC2739419
MID - NIHMS136586
EDAT- 2009/07/18 09:00
MHDA- 2009/11/05 06:00
PMCR- 2010/11/15
CRDT- 2009/07/18 09:00
PHST- 2009/03/03 00:00 [received]
PHST- 2009/06/29 00:00 [revised]
PHST- 2009/07/03 00:00 [accepted]
PHST- 2009/07/18 09:00 [entrez]
PHST- 2009/07/18 09:00 [pubmed]
PHST- 2009/11/05 06:00 [medline]
PHST- 2010/11/15 00:00 [pmc-release]
AID - S1053-8119(09)00766-6 [pii]
AID - 10.1016/j.neuroimage.2009.07.006 [doi]
PST - ppublish
SO  - Neuroimage. 2009 Nov 15;48(3):515-24. doi: 10.1016/j.neuroimage.2009.07.006. Epub 
      2009 Jul 14.