PMID- 19608014
OWN - NLM
STAT- MEDLINE
DCOM- 20090928
LR  - 20090717
IS  - 1873-5487 (Electronic)
IS  - 0188-4409 (Linking)
VI  - 40
IP  - 4
DP  - 2009 May
TI  - Downregulation of HLA class I molecules in primary oral squamous cell carcinomas 
      and cell lines.
PG  - 256-63
LID - 10.1016/j.arcmed.2009.04.004 [doi]
AB  - BACKGROUND AND AIMS: Loss or downregulation of human leukocyte antigen (HLA) 
      class I expression has been reported in a variety of human tumors including oral 
      squamous cell carcinoma (OSCC). METHODS: Expression of HLA class I molecules were 
      evaluated by immunohistochemistry, flow cytometry, semi-quantitative Western blot 
      and RT-PCR in 43 tissue samples of primary oral squamous cell carcinomas (pOSCC) 
      from Chinese patients and two OSCC cell lines. RESULTS: HLA class I heavy chain 
      of B/C locus and A locus and beta(2-)microglobulin were obviously lost or 
      downregulated in pOSCC with the percentage of 31, 55 and 35% respectively. The 
      expression of HLA B/C, LMP2, LMP7, LMP10 and PA28beta in OSCC cell lines was also 
      presumably reduced in comparison with normal epithelial cell line. CONCLUSIONS: 
      These data suggested that the downregulation of HLA class I molecules in OSCC was 
      closely associated with the low-efficient transcription and abnormality of 
      post-transcription regulation of HLA class I genes and antigen 
      presentation-related genes. These results can add more light to the mechanism by 
      which OSCC escape from immunological surveillance.
FAU - Tang, Qiusha
AU  - Tang Q
AD  - The Key Laboratory of Developmental Genes and Human Disease of Education 
      Ministry, Department of Genetics and Developmental Biology, Southeast University 
      Medical School, Jiangsu Province, China.
FAU - Zhang, Jianqiong
AU  - Zhang J
FAU - Qi, Bing
AU  - Qi B
FAU - Shen, Chuanlai
AU  - Shen C
FAU - Xie, Wei
AU  - Xie W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090521
PL  - United States
TA  - Arch Med Res
JT  - Archives of medical research
JID - 9312706
RN  - 0 (Antiviral Agents)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (beta 2-Microglobulin)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Antiviral Agents/pharmacology
MH  - Carcinoma, Squamous Cell/genetics/*immunology
MH  - Cell Line, Tumor
MH  - Down-Regulation
MH  - *Gene Expression Regulation, Neoplastic
MH  - Histocompatibility Antigens Class I/*genetics/immunology
MH  - Humans
MH  - Immunologic Surveillance/*genetics
MH  - Interferon-gamma/pharmacology
MH  - Mouth Neoplasms/genetics/*immunology
MH  - beta 2-Microglobulin/immunology
EDAT- 2009/07/18 09:00
MHDA- 2009/09/29 06:00
CRDT- 2009/07/18 09:00
PHST- 2008/12/06 00:00 [received]
PHST- 2009/03/30 00:00 [accepted]
PHST- 2009/07/18 09:00 [entrez]
PHST- 2009/07/18 09:00 [pubmed]
PHST- 2009/09/29 06:00 [medline]
AID - S0188-4409(09)00059-9 [pii]
AID - 10.1016/j.arcmed.2009.04.004 [doi]
PST - ppublish
SO  - Arch Med Res. 2009 May;40(4):256-63. doi: 10.1016/j.arcmed.2009.04.004. Epub 2009 
      May 21.