PMID- 19608167
OWN - NLM
STAT- MEDLINE
DCOM- 20090923
LR  - 20200816
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 92
IP  - 3
DP  - 2009 Sep
TI  - Normal pregnancy after tetraploid karyotype on trophectoderm biopsy.
PG  - 1169.e9-1169.e10
LID - S0015-0282(09)01299-0 [pii]
LID - 10.1016/j.fertnstert.2009.06.007 [doi]
AB  - OBJECTIVE: To report a case of successful pregnancy after trophectoderm biopsy 
      and fluorescence in situ hybridization (FISH) revealed a tetraploid karyotype. 
      DESIGN: Case report. SETTING: A university medical center. PATIENT(S): An 
      infertility patient desiring trophectoderm biopsy on frozen blastocysts to 
      facilitate preimplantation genetic screening. INTERVENTION(S): Frozen blastocysts 
      were thawed on the evening before transfer. Trophectoderm biopsy was performed 
      the following morning. FISH results were available the same day, and two embryos 
      with tetraploid results were transferred. MAIN OUTCOME MEASURE(S): Chorionic 
      villus sample (CVS) and newborn exam. RESULT(S): Normal diploid CVS result and a 
      healthy male infant. CONCLUSION(S): Although multiple cells can be analyzed using 
      trophectoderm biopsy, abnormalities in the trophectoderm may not be present in 
      the inner cell mass.
FAU - Krieg, Sacha A
AU  - Krieg SA
AD  - Division of Reproductive Endocrinology and Infertility, Stanford Hospital and 
      Clinics, Palo Alto, California.
FAU - Lathi, Ruth B
AU  - Lathi RB
AD  - Division of Reproductive Endocrinology and Infertility, Stanford Hospital and 
      Clinics, Palo Alto, California.
FAU - Behr, Barry
AU  - Behr B
AD  - Division of Reproductive Endocrinology and Infertility, Stanford Hospital and 
      Clinics, Palo Alto, California.
FAU - Westphal, Lynn M
AU  - Westphal LM
AD  - Division of Reproductive Endocrinology and Infertility, Stanford Hospital and 
      Clinics, Palo Alto, California. Electronic address: lynnw@stanford.edu.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20090715
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
SB  - IM
MH  - Adult
MH  - Biopsy
MH  - Blastocyst/*pathology
MH  - *Chromosome Aberrations
MH  - Ectoderm/*pathology
MH  - Embryo Transfer
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infant, Newborn
MH  - Infertility, Female/therapy
MH  - Male
MH  - *Ploidies
MH  - Pregnancy
MH  - Pregnancy Outcome/*genetics
MH  - Preimplantation Diagnosis/*methods
EDAT- 2009/07/18 09:00
MHDA- 2009/09/24 06:00
CRDT- 2009/07/18 09:00
PHST- 2009/04/30 00:00 [received]
PHST- 2009/05/22 00:00 [revised]
PHST- 2009/06/02 00:00 [accepted]
PHST- 2009/07/18 09:00 [entrez]
PHST- 2009/07/18 09:00 [pubmed]
PHST- 2009/09/24 06:00 [medline]
AID - S0015-0282(09)01299-0 [pii]
AID - 10.1016/j.fertnstert.2009.06.007 [doi]
PST - ppublish
SO  - Fertil Steril. 2009 Sep;92(3):1169.e9-1169.e10. doi: 
      10.1016/j.fertnstert.2009.06.007. Epub 2009 Jul 15.