PMID- 19615354
OWN - NLM
STAT- MEDLINE
DCOM- 20091222
LR  - 20221207
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 408
IP  - 1-2
DP  - 2009 Oct
TI  - Association of serum glycated albumin, C-reactive protein and ICAM-1 levels with 
      diffuse coronary artery disease in patients with type 2 diabetes mellitus.
PG  - 45-9
LID - 10.1016/j.cca.2009.07.003 [doi]
AB  - BACKGROUND: We assessed the possible association of glycated albumin (GA) and 
      circulatory adhesion molecules with diffuse coronary artery disease (CAD) in 
      patients with type 2 diabetes mellitus (T2DM). METHODS: Six hundred and two 
      consecutive patients with CAD, based upon angiographic features and presence or 
      absence of T2DM, were categorized as Group I (296 patients with non-diffuse CAD 
      but no T2DM), Group II (138 patients with diffuse CAD but no T2DM), Group III (78 
      patients with non-diffuse CAD and T2DM) and Group IV (90 patients with diffuse 
      CAD and T2DM). Serum levels of glycated albumin, adhesion molecules, endogenous 
      secretory receptor of advanced glycation end products (esRAGE) and inflammatory 
      factors were determined. RESULTS: Serum levels of GA, hsCRP, sVCAM-1, sICAM-1 and 
      sE-selectin were increased, while esRAGE levels were decreased in diabetic 
      patients than in non-diabetic patients (all P<0.001). These levels (except 
      sVCAM-1 and sE-selectin) differed between Groups III and IV (all P<0.05). 
      Moreover, GA levels correlated with sE-selectin and sICAM-1 concentrations (both 
      P<0.05). Multivariable regression analysis revealed that male, hypertension, GA, 
      hsCRP and sICAM-1 were independently associated with diffuse CAD in diabetic 
      patients. CONCLUSIONS: This study addresses an association of increased GA, hsCRP 
      and sICAM-1 levels with diffuse CAD in patients with T2DM.
FAU - Jin, Cao
AU  - Jin C
AD  - Department of Cardiology, Rui Jin Hospital, Medical School of Jiaotong 
      University, People's Republic of China.
FAU - Lu, Lin
AU  - Lu L
FAU - Zhang, Rui Yan
AU  - Zhang RY
FAU - Zhang, Qi
AU  - Zhang Q
FAU - Ding, Feng Hua
AU  - Ding FH
FAU - Chen, Qiu Jing
AU  - Chen QJ
FAU - Shen, Wei Feng
AU  - Shen WF
LA  - eng
PT  - Journal Article
DEP - 20090715
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Glycation End Products, Advanced)
RN  - 0 (Interleukin-6)
RN  - 0 (Serum Albumin)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 0 (Glycated Serum Albumin)
SB  - IM
MH  - Aged
MH  - C-Reactive Protein/*metabolism
MH  - Coronary Artery Disease/*blood/*complications/pathology
MH  - Diabetes Mellitus, Type 2/*blood/*complications/pathology
MH  - Endothelial Cells/pathology
MH  - Female
MH  - Glycation End Products, Advanced/blood
MH  - Humans
MH  - Inflammation/blood/complications
MH  - Intercellular Adhesion Molecule-1/*blood
MH  - Interleukin-6/blood
MH  - Male
MH  - Multivariate Analysis
MH  - Regression Analysis
MH  - Serum Albumin/*metabolism
MH  - Tumor Necrosis Factor-alpha/blood
MH  - Glycated Serum Albumin
EDAT- 2009/07/21 09:00
MHDA- 2009/12/23 06:00
CRDT- 2009/07/21 09:00
PHST- 2009/05/09 00:00 [received]
PHST- 2009/07/03 00:00 [revised]
PHST- 2009/07/03 00:00 [accepted]
PHST- 2009/07/21 09:00 [entrez]
PHST- 2009/07/21 09:00 [pubmed]
PHST- 2009/12/23 06:00 [medline]
AID - S0009-8981(09)00391-X [pii]
AID - 10.1016/j.cca.2009.07.003 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2009 Oct;408(1-2):45-9. doi: 10.1016/j.cca.2009.07.003. Epub 2009 
      Jul 15.