PMID- 19615366
OWN - NLM
STAT- MEDLINE
DCOM- 20090929
LR  - 20090914
IS  - 1090-2430 (Electronic)
IS  - 0014-4886 (Linking)
VI  - 219
IP  - 2
DP  - 2009 Oct
TI  - Turn-over of meningeal and perivascular macrophages in the brain of MCP-1-, 
      CCR-2- or double knockout mice.
PG  - 583-5
LID - 10.1016/j.expneurol.2009.07.003 [doi]
AB  - Perivascular and meningeal macrophages are important for immune surveillance in 
      the healthy and the injured brain. Monocyte chemoattractant protein-1 (MCP-1) 
      regulates macrophage migration and permeability of the blood brain barrier. In 
      the present study, we investigated the influence of MCP-1 or/and chemokine 
      receptor 2 (CCR2)-deficiency on macrophage turnover. The results showed no 
      influence of single MCP-1- or CCR-2-deficiency, but double-deficient mice 
      revealed a virtual absence of blood-borne macrophage recruitment. This finding 
      emphasizes that the MCP-1/CCR2 axis is crucially important for macrophage 
      turnover and compensatory mechanisms remain only partially sufficient to sustain 
      regulatory functions.
FAU - Schilling, Matthias
AU  - Schilling M
AD  - Department of Neurology, University Hospital Munster, Munster, Germany. 
      schillim@uni-muenster.de
FAU - Strecker, Jan-Kolja
AU  - Strecker JK
FAU - Ringelstein, E Bernd
AU  - Ringelstein EB
FAU - Kiefer, Reinhard
AU  - Kiefer R
FAU - Schabitz, Wolf-Rudiger
AU  - Schabitz WR
LA  - eng
PT  - Journal Article
DEP - 20090715
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - 0 (Antigens, Differentiation)
RN  - 0 (Ccr2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Receptors, CCR2)
RN  - 0 (monocyte-macrophage differentiation antigen)
RN  - 147336-22-9 (Green Fluorescent Proteins)
SB  - IM
MH  - Animals
MH  - Antigens, Differentiation/metabolism
MH  - Chemokine CCL2/deficiency/genetics/*metabolism
MH  - Green Fluorescent Proteins/genetics
MH  - Macrophages/*metabolism
MH  - Meninges/*cytology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Receptors, CCR2/deficiency/genetics/*metabolism
EDAT- 2009/07/21 09:00
MHDA- 2009/09/30 06:00
CRDT- 2009/07/21 09:00
PHST- 2009/03/01 00:00 [received]
PHST- 2009/06/30 00:00 [revised]
PHST- 2009/07/06 00:00 [accepted]
PHST- 2009/07/21 09:00 [entrez]
PHST- 2009/07/21 09:00 [pubmed]
PHST- 2009/09/30 06:00 [medline]
AID - S0014-4886(09)00268-4 [pii]
AID - 10.1016/j.expneurol.2009.07.003 [doi]
PST - ppublish
SO  - Exp Neurol. 2009 Oct;219(2):583-5. doi: 10.1016/j.expneurol.2009.07.003. Epub 
      2009 Jul 15.