PMID- 19615795
OWN - NLM
STAT- MEDLINE
DCOM- 20100818
LR  - 20211203
IS  - 1532-1940 (Electronic)
IS  - 0266-4356 (Linking)
VI  - 48
IP  - 4
DP  - 2010 Jun
TI  - Mammalian target of rapamycin (mTOR) is involved in the survival of cells 
      mediated by chemokine receptor 7 through PI3K/Akt in metastatic squamous cell 
      carcinoma of the head and neck.
PG  - 291-6
LID - 10.1016/j.bjoms.2009.06.007 [doi]
AB  - Metastatic squamous cell carcinoma (SCC) of the head and neck expresses chemokine 
      receptor 7 (CCR7), which activates phosphoinositide-3 kinase (PI3K) to promote 
      invasion and survival of SCC cells in the head and neck. We hypothesised that 
      mammalian target of rapamycin (mTOR) may be the downstream molecule of the 
      CCR7-PI3K pathway. Results have shown that interaction between CCR7 and its 
      ligand CCL19 induces the phosphorylation of mTOR and its target p70s6k. This 
      phosphorylation is abolished by inhibition of CCR7 and PI3K/Akt, indicating that 
      mTOR is involved in the CCR7-PI3K cascade. The inhibitors of mTOR and CCR7-PI3K 
      also lead to a significant increase in CCL19-induced death, apoptosis, and 
      cell-cycle arrest of metastatic SCC cells in the head and neck. Taken together, 
      our data indicate the important part played by mTOR in CCR7-induced survival of 
      such SCC cells.
CI  - Copyright 2009 The British Association of Oral and Maxillofacial Surgeons. 
      Published by Elsevier Ltd. All rights reserved.
FAU - Liu, Fa-Yu
AU  - Liu FY
AD  - Oral and Maxillofacial Tumor Center, Department of Oral and Maxillofacial 
      Surgery, School of Stomatology, China Medical University, No. 117, Nanjing Bei 
      Jie, Heping District, Shenyang, Liaoning 110002, China.
FAU - Zhao, Zhen-Jin
AU  - Zhao ZJ
FAU - Li, Peng
AU  - Li P
FAU - Ding, Xue
AU  - Ding X
FAU - Zong, Zhi-Hong
AU  - Zong ZH
FAU - Sun, Chang-Fu
AU  - Sun CF
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090716
PL  - Scotland
TA  - Br J Oral Maxillofac Surg
JT  - The British journal of oral & maxillofacial surgery
JID - 8405235
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (CCL19 protein, human)
RN  - 0 (CCR7 protein, human)
RN  - 0 (Chemokine CCL19)
RN  - 0 (Chromones)
RN  - 0 (Coloring Agents)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Morpholines)
RN  - 0 (Phosphoinositide-3 Kinase Inhibitors)
RN  - 0 (Receptors, CCR7)
RN  - 0 (Tetrazolium Salts)
RN  - 0 (Thiazoles)
RN  - 31M2U1DVID (2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.1 (Ribosomal Protein S6 Kinases, 70-kDa)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EUY85H477I (thiazolyl blue)
RN  - Q20Q21Q62J (Cisplatin)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Antibodies, Monoclonal
MH  - Antineoplastic Agents/pharmacology
MH  - Apoptosis/drug effects
MH  - Blotting, Western
MH  - Carcinoma, Squamous Cell/pathology/*secondary
MH  - Cell Cycle/drug effects
MH  - Cell Death/drug effects
MH  - Cell Line, Tumor
MH  - Cell Survival/drug effects/physiology
MH  - Chemokine CCL19/physiology
MH  - Chromones/pharmacology
MH  - Cisplatin/pharmacology
MH  - Coloring Agents
MH  - Enzyme Inhibitors/pharmacology
MH  - Flow Cytometry
MH  - Head and Neck Neoplasms/pathology/*secondary
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins/antagonists & 
      inhibitors/*physiology
MH  - Morpholines/pharmacology
MH  - Neoplasm Invasiveness
MH  - Phosphatidylinositol 3-Kinases/*physiology
MH  - Phosphoinositide-3 Kinase Inhibitors
MH  - Phosphorylation
MH  - Polymerase Chain Reaction/methods
MH  - Protein Serine-Threonine Kinases/antagonists & inhibitors/*physiology
MH  - Proto-Oncogene Proteins c-akt/antagonists & inhibitors/*physiology
MH  - Receptors, CCR7/antagonists & inhibitors/*physiology
MH  - Ribosomal Protein S6 Kinases, 70-kDa/physiology
MH  - Sirolimus/pharmacology
MH  - TOR Serine-Threonine Kinases
MH  - Tetrazolium Salts
MH  - Thiazoles
EDAT- 2009/07/21 09:00
MHDA- 2010/08/19 06:00
CRDT- 2009/07/21 09:00
PHST- 2009/06/11 00:00 [accepted]
PHST- 2009/07/21 09:00 [entrez]
PHST- 2009/07/21 09:00 [pubmed]
PHST- 2010/08/19 06:00 [medline]
AID - S0266-4356(09)00224-1 [pii]
AID - 10.1016/j.bjoms.2009.06.007 [doi]
PST - ppublish
SO  - Br J Oral Maxillofac Surg. 2010 Jun;48(4):291-6. doi: 
      10.1016/j.bjoms.2009.06.007. Epub 2009 Jul 16.