PMID- 19616923
OWN - NLM
STAT- MEDLINE
DCOM- 20091209
LR  - 20221207
IS  - 1873-7862 (Electronic)
IS  - 0924-977X (Linking)
VI  - 19
IP  - 11
DP  - 2009 Nov
TI  - Clomipramine treatment reversed the glial pathology in a chronic unpredictable 
      stress-induced rat model of depression.
PG  - 796-805
LID - 10.1016/j.euroneuro.2009.06.010 [doi]
AB  - Growing evidence indicates that glia pathology contributes to the pathophysiology 
      and possibly the etiology of depression. The study investigates changes in 
      behaviors and glial fibrillary associated protein (GFAP) in the rat hippocampus 
      after chronic unpredictable stress (CUS), a rat model of depression. Furthermore, 
      we studied the effects of clomipramine, one of tricyclic antidepressants (TCAs), 
      known to modulate serotonin and norepinephrine uptake, on CUS-induced 
      depressive-like behaviors and GFAP levels. Rats exposed to CUS showed behavioral 
      deficits in physical state, open field test and forced swimming test and 
      exhibited a significant decrease in GFAP expression in the hippocampus. 
      Interestingly, the behavioral and GFAP expression changes induced by CUS were 
      reversed by chronic treatment with the antidepressant clomipramine. The 
      beneficial effects of clomipramine treatment on CUS-induced depressive-like 
      behavior and GFAP expression provide further validation of our hypothesis that 
      glial dysfunction contributes to the pathophysiology of depression and that glial 
      elements may represent viable targets for new antidepressant drug development.
FAU - Liu, Qiong
AU  - Liu Q
AD  - Institute of Acupuncture Research (WHO Collaborating Center for Traditional 
      Medicine), Institutes of Brain Science, Department of Integrative Medicine and 
      Neurobiology, State Key Laboratory of Medical Neurobiology, Shanghai Medical 
      College, Fudan University, Shanghai 200032, China.
FAU - Li, Bing
AU  - Li B
FAU - Zhu, Hai-Yan
AU  - Zhu HY
FAU - Wang, Yan-Qing
AU  - Wang YQ
FAU - Yu, Jin
AU  - Yu J
FAU - Wu, Gen-Cheng
AU  - Wu GC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090718
PL  - Netherlands
TA  - Eur Neuropsychopharmacol
JT  - European neuropsychopharmacology : the journal of the European College of 
      Neuropsychopharmacology
JID - 9111390
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (RNA, Messenger)
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - NUV44L116D (Clomipramine)
SB  - IM
MH  - Animals
MH  - Clomipramine/*pharmacology/therapeutic use
MH  - *Depression/drug therapy/etiology/pathology
MH  - Disease Models, Animal
MH  - Exploratory Behavior/drug effects
MH  - Freezing Reaction, Cataleptic
MH  - Gene Expression Regulation/drug effects
MH  - Glial Fibrillary Acidic Protein/genetics/metabolism
MH  - Hippocampus/drug effects/pathology
MH  - Male
MH  - Neuroglia/*drug effects/metabolism/pathology
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Selective Serotonin Reuptake Inhibitors/*pharmacology/therapeutic use
MH  - Stress, Psychological/*complications
MH  - Swimming
EDAT- 2009/07/21 09:00
MHDA- 2009/12/16 06:00
CRDT- 2009/07/21 09:00
PHST- 2009/02/19 00:00 [received]
PHST- 2009/05/26 00:00 [revised]
PHST- 2009/06/09 00:00 [accepted]
PHST- 2009/07/21 09:00 [entrez]
PHST- 2009/07/21 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
AID - S0924-977X(09)00162-X [pii]
AID - 10.1016/j.euroneuro.2009.06.010 [doi]
PST - ppublish
SO  - Eur Neuropsychopharmacol. 2009 Nov;19(11):796-805. doi: 
      10.1016/j.euroneuro.2009.06.010. Epub 2009 Jul 18.