PMID- 19617694
OWN - NLM
STAT- MEDLINE
DCOM- 20090730
LR  - 20090720
IS  - 1424-859X (Electronic)
IS  - 1424-8581 (Linking)
VI  - 125
IP  - 1
DP  - 2009
TI  - Evolutionary break point analysis between the proximal half of bovine chromosome 
      27 and conserved segments of the human genome.
PG  - 33-9
LID - 10.1159/000218746 [doi]
AB  - The proximal half of Bos taurus chromosome 27 (BTA27prox) delimited by 
      microsatellite markers BM3507 and CSSM043 reveals complex rearrangements compared 
      to its corresponding Homo sapiens chromosome (HSA) fragments. A comparative 
      mapping approach combining somatic and radiation hybrid cell mapping techniques 
      and related cytogenetic data resulted in an improved physical map for BTA27prox, 
      which provides candidate genes for several important economic traits. The 
      generated comprehensive map includes anchor loci for 103 genes and microsatellite 
      markers. Mapping of genes proximal to BM3507 matching a region from 0.60 to 2.78 
      megabase pairs (Mb) of HSA8 confirmed recent sequence annotations on BTA27. 
      Assignments of loci predicted to be on BTA27 to BTA1, BTA8, and BTA17 narrowed 
      down evolutionary chromosome break points compared with corresponding chromosome 
      segments in human. New physical anchors obtained in this study confirm in more 
      detail the described evolutionary conservation between the proximal half of BTA27 
      and homologous segments of HSA4 and HSA8 and will contribute to the completion of 
      the cattle DNA genome sequence.
CI  - Copyright 2009 S. Karger AG, Basel.
FAU - Goldammer, T
AU  - Goldammer T
AD  - Research Institute for the Biology of Farm Animals, Research Unit of Molecular 
      Biology, Dummerstorf, Germany. tomgoldammer@fbn-dummerstorf.de
FAU - Kuehn, C
AU  - Kuehn C
FAU - Brunner, R M
AU  - Brunner RM
FAU - Weikard, R
AU  - Weikard R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090714
PL  - Switzerland
TA  - Cytogenet Genome Res
JT  - Cytogenetic and genome research
JID - 101142708
SB  - IM
MH  - Animals
MH  - Cattle/*genetics
MH  - Chromosome Breakage
MH  - Chromosome Mapping
MH  - Evolution, Molecular
MH  - *Genome, Human
MH  - Humans
MH  - Microsatellite Repeats
MH  - Radiation Hybrid Mapping
MH  - Species Specificity
MH  - *Synteny
EDAT- 2009/07/21 09:00
MHDA- 2009/07/31 09:00
CRDT- 2009/07/21 09:00
PHST- 2009/02/12 00:00 [accepted]
PHST- 2009/07/21 09:00 [entrez]
PHST- 2009/07/21 09:00 [pubmed]
PHST- 2009/07/31 09:00 [medline]
AID - 000218746 [pii]
AID - 10.1159/000218746 [doi]
PST - ppublish
SO  - Cytogenet Genome Res. 2009;125(1):33-9. doi: 10.1159/000218746. Epub 2009 Jul 14.