PMID- 19618672
OWN - NLM
STAT- MEDLINE
DCOM- 20090918
LR  - 20131121
IS  - 0031-7144 (Print)
IS  - 0031-7144 (Linking)
VI  - 64
IP  - 6
DP  - 2009 Jun
TI  - Differential pulse polarographic investigation of lansoprazole and rabeprazole 
      using dropping mercury electrode.
PG  - 371-5
AB  - The electrochemical reduction of the proton pump inhibitors (PPI) lansoprazole 
      and rabeprazole has been investigated by differential pulse polarography (DPP) 
      using a dropping mercury electrode (DME). The results were compared not only 
      among both substances but also among other proton pump inhibitors depending on 
      the varying chemical structures of the agents. All investigations were carried 
      out in Britton-Robinson buffer solutions with pH values from 3.0 to 11.0. It was 
      shown that both PPI undergo an extensive decomposition decreasing with increasing 
      pH values forming two main compounds, a cyclic sulfenamide and a dimer. In this 
      case lansoprazole was found to be stable at pH 8.0 and rabeprazole at pH 9.0. The 
      decomposition of rabeprazole ran considerably quicker and also up to higher pH 
      values than those of lansoprazole. The peak currents varied linearly with the 
      concentration of both PPI in the range from 1 x 10(-6) M to 7 x 10(-5) M at pH 
      9.0. Both substances showed similarities in reaction as well as individual 
      differences based on their varying chemical structures and characteristics.
FAU - Gartner, P
AU  - Gartner P
AD  - Hospital Pharmacy, University Hospital Carl Gustav Carus, Technical University, 
      Dresden, Germany. peter.gaertner@uniklinikum-dresden.de
FAU - Zschimmer, K
AU  - Zschimmer K
FAU - Knoth, H
AU  - Knoth H
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Pharmazie
JT  - Die Pharmazie
JID - 9800766
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Acids)
RN  - 0 (Anti-Ulcer Agents)
RN  - 0K5C5T2QPG (Lansoprazole)
RN  - 32828355LL (Rabeprazole)
RN  - FXS1BY2PGL (Mercury)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles/*analysis
MH  - Acids/chemistry
MH  - Anti-Ulcer Agents/*analysis
MH  - Electrochemistry
MH  - Electrodes
MH  - Hydrogen-Ion Concentration
MH  - Lansoprazole
MH  - Mercury/chemistry
MH  - Polarography
MH  - Rabeprazole
EDAT- 2009/07/22 09:00
MHDA- 2009/09/19 06:00
CRDT- 2009/07/22 09:00
PHST- 2009/07/22 09:00 [entrez]
PHST- 2009/07/22 09:00 [pubmed]
PHST- 2009/09/19 06:00 [medline]
PST - ppublish
SO  - Pharmazie. 2009 Jun;64(6):371-5.