PMID- 19622039
OWN - NLM
STAT- MEDLINE
DCOM- 20091026
LR  - 20220330
IS  - 1557-7430 (Electronic)
IS  - 1044-5498 (Linking)
VI  - 28
IP  - 10
DP  - 2009 Oct
TI  - Interleukin-18 gene promoter polymorphism and the risk of nasopharyngeal 
      carcinoma in a Chinese population.
PG  - 507-13
LID - 10.1089/dna.2009.0912 [doi]
AB  - Nasopharyngeal carcinoma (NPC) is one of the most common cancers in southern 
      China. In addition to environmental factors such as Epstein-Barr virus infection 
      and chemical carcinogen exposure, genetic susceptibility has been reported to 
      play a key role in the development of this disease. Interleukin-18 (IL-18) is a 
      multifunctional cytokine that induces interferon-gamma secretion and plays an 
      important role in antitumor immunity. Variations in the DNA sequence of the IL-18 
      gene promoter may lead to altered IL-18 production and/or activity, so this can 
      modulate an individual's susceptibility to NPC. To test this hypothesis, we 
      analyzed two single-nucleotide polymorphisms of IL-18 gene promoter, -137 G/C and 
      -607 C/A, in 250 patients with NPC and 270 age- and sex-matched controls, using 
      polymerase chain reaction-restriction fragment length polymorphism. Two 
      polymorphisms, -137 G/C and -607 C/A, were in strong linkage disequilibrium. 
      There were significant differences in the genotype and allele distribution of 
      -137 G/C polymorphism of the IL-18 gene among cases and controls. The -137 GC and 
      CC genotypes were associated with a significantly increased risk of NPC as 
      compared with the -137 GG genotypes (odds ratio [OR] = 1.697; 95% confidence 
      interval [CI], 1.158-2.488; p = 0.007, and OR = 2.700; 95% CI, 1.268-5.751; p = 
      0.008, respectively). Consistent with the results of the genotyping analyses, the 
      -137 C/-607 A haplotype was associated with a significantly increased risk of NPC 
      as compared with the -137 G/-607 C haplotype (OR = 1.721; 95% CI, 1.262-2.349; p 
      = 0.001).
FAU - Nong, Le-Gen
AU  - Nong LG
AD  - Department of Medical Laboratory, Affiliated Hospital of Youjiang Medical 
      University for Nationalities, Baise, China. nonglegen@gmail.com
FAU - Luo, Bin
AU  - Luo B
FAU - Zhang, Liang
AU  - Zhang L
FAU - Nong, Hong-Bing
AU  - Nong HB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - DNA Cell Biol
JT  - DNA and cell biology
JID - 9004522
RN  - 0 (DNA Primers)
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Base Sequence
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - DNA Primers
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Haplotypes
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Linkage Disequilibrium
MH  - Male
MH  - Middle Aged
MH  - Nasopharyngeal Neoplasms/epidemiology/*genetics
MH  - *Polymorphism, Genetic
MH  - *Promoter Regions, Genetic
MH  - Risk Factors
EDAT- 2009/07/23 09:00
MHDA- 2009/10/27 06:00
CRDT- 2009/07/23 09:00
PHST- 2009/07/23 09:00 [entrez]
PHST- 2009/07/23 09:00 [pubmed]
PHST- 2009/10/27 06:00 [medline]
AID - 10.1089/dna.2009.0912 [doi]
PST - ppublish
SO  - DNA Cell Biol. 2009 Oct;28(10):507-13. doi: 10.1089/dna.2009.0912.