PMID- 19622083
OWN - NLM
STAT- MEDLINE
DCOM- 20100217
LR  - 20211020
IS  - 1399-5448 (Electronic)
IS  - 1399-543X (Print)
IS  - 1399-543X (Linking)
VI  - 10
IP  - 8
DP  - 2009 Dec
TI  - An exploration of Glo-3A antibody levels in children at increased risk for type 1 
      diabetes mellitus.
PG  - 563-72
LID - 10.1111/j.1399-5448.2009.00541.x [doi]
AB  - AIMS: To determine whether Glo-3A, (formerly referred to as homologue of Glb1 or 
      Glb1) antibodies are associated with islet autoimmunity (IA) in children at 
      increased risk for type 1 diabetes (T1D) and to investigate their relation with 
      environmental correlates of T1D. METHODS: We selected a sample from the Diabetes 
      Autoimmunity Study in the Young (DAISY), a prospective study of children at 
      increased risk for T1D. Cases were positive for insulin, glutamic acid 
      decarboxylase (GAD), or insulinoma-associated antigen-2 (IA-2) autoantibodies on 
      two consecutive visits and either diagnosed with diabetes mellitus or still 
      autoantibody positive when selected. Controls were from the same increased risk 
      group, of similar age as the cases but negative for autoantibodies. Sera from 91 
      IA cases and 82 controls were analyzed in a blinded manner for immunoglobulin G 
      (IgG) antibodies to Glo-3A by ELISA. RESULTS: Adjusting for family history of T1D 
      and human leukocyte antigen (HLA)-DR4 positivity, Glo-3A antibodies were not 
      associated with IA case status (OR: 1.01, 95% CI: 0.99-1.03). Adjusting for age, 
      family history of T1D, and HLA-DR4 positivity, Glo-3A antibody levels were 
      inversely associated with breast-feeding duration (beta = -0.08, p = 0.001) and 
      directly associated with current intake of foods containing gluten (beta = 0.24, 
      p = 0.007) in IA cases but not in controls. Zonulin, a biomarker of gut 
      permeability, was directly associated with Glo-3A antibody levels in cases (beta 
      = 0.73, p = 0.003) but not in controls. CONCLUSION: Differing correlates of 
      Glo-3A antibodies in IA cases and controls suggest an underlying difference in 
      mucosal immune response.
FAU - Simpson, M
AU  - Simpson M
AD  - Department of Epidemiology, Colorado School of Public Health, Colorado, USA.
FAU - Mojibian, M
AU  - Mojibian M
FAU - Barriga, K
AU  - Barriga K
FAU - Scott, F W
AU  - Scott FW
FAU - Fasano, A
AU  - Fasano A
FAU - Rewers, M
AU  - Rewers M
FAU - Norris, J M
AU  - Norris JM
LA  - eng
GR  - R01 DK032493-16/DK/NIDDK NIH HHS/United States
GR  - R01 DK050979/DK/NIDDK NIH HHS/United States
GR  - R01 DK049654/DK/NIDDK NIH HHS/United States
GR  - R01 DK049654-03/DK/NIDDK NIH HHS/United States
GR  - R01 DK032493/DK/NIDDK NIH HHS/United States
PT  - Journal Article
DEP - 20090720
PL  - Denmark
TA  - Pediatr Diabetes
JT  - Pediatric diabetes
JID - 100939345
RN  - 0 (Autoantibodies)
RN  - 0 (Haptoglobins)
RN  - 0 (ICA512 autoantibody)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Protein Precursors)
RN  - 0 (zonulin)
RN  - 9007-90-3 (Gliadin)
RN  - 9012-63-9 (Cholera Toxin)
RN  - EC 4.1.1.15 (Glutamate Decarboxylase)
SB  - IM
MH  - Autoantibodies/*blood
MH  - Celiac Disease/*epidemiology/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Cholera Toxin/metabolism
MH  - Diabetes Mellitus, Type 1/*epidemiology/*immunology
MH  - Female
MH  - Gliadin/immunology
MH  - Glutamate Decarboxylase/immunology
MH  - Haptoglobins
MH  - Humans
MH  - Immunoglobulin G/blood
MH  - Infant
MH  - Intestinal Absorption/immunology
MH  - Islets of Langerhans/immunology
MH  - Male
MH  - Prospective Studies
MH  - Protein Precursors
MH  - Risk Factors
MH  - Seroepidemiologic Studies
PMC - PMC2814050
MID - NIHMS171434
EDAT- 2009/07/23 09:00
MHDA- 2010/02/18 06:00
PMCR- 2010/12/01
CRDT- 2009/07/23 09:00
PHST- 2009/07/23 09:00 [entrez]
PHST- 2009/07/23 09:00 [pubmed]
PHST- 2010/02/18 06:00 [medline]
PHST- 2010/12/01 00:00 [pmc-release]
AID - PDI541 [pii]
AID - 10.1111/j.1399-5448.2009.00541.x [doi]
PST - ppublish
SO  - Pediatr Diabetes. 2009 Dec;10(8):563-72. doi: 10.1111/j.1399-5448.2009.00541.x. 
      Epub 2009 Jul 20.