PMID- 19622720
OWN - NLM
STAT- MEDLINE
DCOM- 20091020
LR  - 20211203
IS  - 1538-7755 (Electronic)
IS  - 1055-9965 (Linking)
VI  - 18
IP  - 8
DP  - 2009 Aug
TI  - Maternal immunoglobulin E and childhood leukemia.
PG  - 2221-7
LID - 10.1158/1055-9965.EPI-09-0212 [doi]
AB  - Childhood leukemia, particularly acute lymphoblastic leukemia (ALL), has long 
      been hypothesized to be affected by abnormal immune responses to microbial 
      challenges stemming from a lack of immune modulation in early childhood. Studies 
      of allergies suggest that a child's immune development may be modulated by 
      maternal immune status. We conducted a study to explore the relationship between 
      maternal immunoglobulin E (IgE) and childhood leukemia and to investigate whether 
      maternal immune status can influence childhood leukemia risk. Serum total and 
      specific IgE (respiratory and food) were measured in biological mothers of 352 
      children (193 healthy controls and 159 leukemia cases, including 139 ALL cases) 
      ages <8 years who were enrolled in the Northern California Childhood Leukemia 
      Study. Odds ratios associated with maternal IgE were calculated using 
      unconditional logistic regression adjusted for child's age, sex, race/ethnicity, 
      and annual household income. A positive association between childhood leukemia or 
      ALL and elevated levels of maternal serum total IgE was observed, especially 
      among Hispanics. In addition, a positive association was observed between 
      childhood leukemia or ALL and maternal respiratory or food IgE status. These 
      results suggest that maternal immune function may play a crucial role in the 
      etiology of childhood leukemia, although additional studies need to be conducted 
      to confirm the results of this study and provide a perspective on mechanisms.
FAU - Chang, Jeffrey S
AU  - Chang JS
AD  - Department of Epidemiology and Biostatistics, University of California-San 
      Francisco, San Francisco, CA 94143-1215, USA. c_jeffrey@hotmail.com
FAU - Buffler, Patricia A
AU  - Buffler PA
FAU - Metayer, Catherine
AU  - Metayer C
FAU - Chokkalingam, Anand P
AU  - Chokkalingam AP
FAU - Patoka, Joe
AU  - Patoka J
FAU - Kronish, Daniel
AU  - Kronish D
FAU - Wiemels, Joseph L
AU  - Wiemels JL
LA  - eng
GR  - PS42 ES04705/ES/NIEHS NIH HHS/United States
GR  - R01 ES09137/ES/NIEHS NIH HHS/United States
GR  - R25 CA112355/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20090721
PL  - United States
TA  - Cancer Epidemiol Biomarkers Prev
JT  - Cancer epidemiology, biomarkers & prevention : a publication of the American 
      Association for Cancer Research, cosponsored by the American Society of 
      Preventive Oncology
JID - 9200608
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Hispanic or Latino
MH  - Humans
MH  - Hypersensitivity/complications/immunology
MH  - Immunoglobulin E/*blood/immunology
MH  - Leukemia/*immunology
MH  - Male
MH  - *Mothers
MH  - Odds Ratio
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*immunology
MH  - Risk Factors
EDAT- 2009/07/23 09:00
MHDA- 2009/10/21 06:00
CRDT- 2009/07/23 09:00
PHST- 2009/07/23 09:00 [entrez]
PHST- 2009/07/23 09:00 [pubmed]
PHST- 2009/10/21 06:00 [medline]
AID - 1055-9965.EPI-09-0212 [pii]
AID - 10.1158/1055-9965.EPI-09-0212 [doi]
PST - ppublish
SO  - Cancer Epidemiol Biomarkers Prev. 2009 Aug;18(8):2221-7. doi: 
      10.1158/1055-9965.EPI-09-0212. Epub 2009 Jul 21.