PMID- 19625220
OWN - NLM
STAT- MEDLINE
DCOM- 20091008
LR  - 20211020
IS  - 1521-7035 (Electronic)
IS  - 1521-6616 (Print)
IS  - 1521-6616 (Linking)
VI  - 133
IP  - 1
DP  - 2009 Oct
TI  - Folate/homocysteine phenotypes and MTHFR 677C>T genotypes are associated with 
      serum levels of monocyte chemoattractant protein-1.
PG  - 132-7
LID - 10.1016/j.clim.2009.06.008 [doi]
AB  - Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that recruits monocytes 
      into the subendothelial cell layer in atherosclerotic lesions. Elevated 
      homocysteine (hyperhomocysteinemia), which is usually associated with low-folate 
      status, is a known risk factor for many pathologies with inflammatory etiologies. 
      The present study was undertaken to examine whether there are associations 
      between MCP-1 concentrations and folate/Hcy phenotype or 
      methylenetetrahydrofolate reductase (MTHFR) 677C>T genotype in healthy young 
      adults. In females, MCP-1 concentrations were positively correlated with Hcy and 
      negatively correlated with both serum and red blood cell folate; female smokers 
      and MTHFR 677T carriers had particularly elevated MCP-1 concentrations. Similar 
      relationships were not seen in males. These findings may have implications for 
      understanding the female predominance observed for a range of autoimmune 
      diseases, such as systemic lupus erythematosus and rheumatoid arthritis.
FAU - Hammons, Andrea L
AU  - Hammons AL
AD  - Department of Pharmacology and Center for Pharmacogenetics, University of 
      Pennsylvania School of Medicine, Philadelphia, PA 19104-6084, USA.
FAU - Summers, Carolyn M
AU  - Summers CM
FAU - Woodside, Jayne V
AU  - Woodside JV
FAU - McNulty, Helene
AU  - McNulty H
FAU - Strain, J J
AU  - Strain JJ
FAU - Young, Ian S
AU  - Young IS
FAU - Murray, Liam
AU  - Murray L
FAU - Boreham, Colin A
AU  - Boreham CA
FAU - Scott, John M
AU  - Scott JM
FAU - Mitchell, Laura E
AU  - Mitchell LE
FAU - Whitehead, Alexander S
AU  - Whitehead AS
LA  - eng
GR  - R01 HD039195/HD/NICHD NIH HHS/United States
GR  - P30 ES013508/ES/NIEHS NIH HHS/United States
GR  - P20 RR020741/RR/NCRR NIH HHS/United States
GR  - ES0P3013508/ES/NIEHS NIH HHS/United States
GR  - R01AR47663/AR/NIAMS NIH HHS/United States
GR  - R01HD039195/HD/NICHD NIH HHS/United States
GR  - P20RR020741/RR/NCRR NIH HHS/United States
GR  - R01 AR047663/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090721
PL  - United States
TA  - Clin Immunol
JT  - Clinical immunology (Orlando, Fla.)
JID - 100883537
RN  - 0 (Chemokine CCL2)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 935E97BOY8 (Folic Acid)
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
SB  - IM
MH  - Adult
MH  - Chemokine CCL2/*blood
MH  - Female
MH  - Folic Acid/*blood
MH  - Genotype
MH  - Heterozygote
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/blood/*genetics
MH  - Male
MH  - Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
MH  - Sex Factors
MH  - Young Adult
PMC - PMC4402225
MID - NIHMS270140
EDAT- 2009/07/25 09:00
MHDA- 2009/10/09 06:00
PMCR- 2015/04/19
CRDT- 2009/07/24 09:00
PHST- 2009/03/05 00:00 [received]
PHST- 2009/06/15 00:00 [revised]
PHST- 2009/06/16 00:00 [accepted]
PHST- 2009/07/24 09:00 [entrez]
PHST- 2009/07/25 09:00 [pubmed]
PHST- 2009/10/09 06:00 [medline]
PHST- 2015/04/19 00:00 [pmc-release]
AID - S1521-6616(09)00703-7 [pii]
AID - 10.1016/j.clim.2009.06.008 [doi]
PST - ppublish
SO  - Clin Immunol. 2009 Oct;133(1):132-7. doi: 10.1016/j.clim.2009.06.008. Epub 2009 
      Jul 21.