PMID- 19625331
OWN - NLM
STAT- MEDLINE
DCOM- 20091030
LR  - 20220331
IS  - 1352-4585 (Print)
IS  - 1352-4585 (Linking)
VI  - 15
IP  - 9
DP  - 2009 Sep
TI  - Brain abnormalities in Sjogren syndrome with recurrent CNS manifestations: 
      association with neuromyelitis optica.
PG  - 1069-76
LID - 10.1177/1352458509106228 [doi]
AB  - BACKGROUND AND OBJECTIVES: Optic neuritis or longitudinally extensive myelitis in 
      Sjogren syndrome (SS) suggests a neuromyelitis optica spectrum disorder (NMOSD). 
      However, brain abnormalities of SS remain to be elucidated for the association 
      with neuromyelitis optica (NMO). METHODS: Twelve primary SS patients (all women, 
      42 +/- 13.2 years) who had recurrent central nervous system (CNS) manifestations 
      with brain involvement were retrospectively identified. Brain MRI, and neurologic 
      and serologic findings were analyzed with the measurement of anti-aquaporin-4 
      antibody (AQP4-Ab). RESULTS: All patients showed brain lesions characteristic of 
      NMO as follows: 1) the involved sites adjacent to the third and fourth ventricles 
      and in the posterior limb of the internal capsule, 2) unique configurations, such 
      as the longitudinal course from the internal capsule to the midbrain, large 
      cerebral or cerebellar lesions over 3 cm, and cavity-like formations. AQP4-Ab was 
      positive in six of eight patients tested, and all the seropositive patients 
      showed lesions with increased diffusion, suggestive of vasogenic edema. Four 
      patients met the revised criteria of NMO, and nine had features of NMOSDs. Of the 
      remaining three patients showing only brain involvement, one had AQP4-Ab. 
      CONCLUSIONS: This study demonstrates that SS patients with recurrent CNS 
      involvement have brain abnormalities characteristic of NMO and AQP4-Ab in Korea. 
      The presence of AQP4-Ab in one SS patient with only brain involvement may suggest 
      that the coexistence of NMO should be explored in SS patients with recurrent CNS 
      manifestations, even without optic neuritis or myelitis.
FAU - Min, J H
AU  - Min JH
AD  - Department of Neurology, Myongji Hospital, Kwandong University College of 
      Medicine, South Korea.
FAU - Kim, H J
AU  - Kim HJ
FAU - Kim, B J
AU  - Kim BJ
FAU - Lee, K W
AU  - Lee KW
FAU - Sunwoo, I N
AU  - Sunwoo IN
FAU - Kim, S M
AU  - Kim SM
FAU - Kim, B J
AU  - Kim BJ
FAU - Kim, S H
AU  - Kim SH
FAU - Park, M S
AU  - Park MS
FAU - Waters, P
AU  - Waters P
FAU - Vincent, A
AU  - Vincent A
FAU - Sung, J J
AU  - Sung JJ
FAU - Lee, K H
AU  - Lee KH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090722
PL  - England
TA  - Mult Scler
JT  - Multiple sclerosis (Houndmills, Basingstoke, England)
JID - 9509185
RN  - 0 (AQP4 protein, human)
RN  - 0 (Aquaporin 4)
SB  - IM
CIN - Mult Scler. 2010 Jun;16(6):762-4. PMID: 20558506
MH  - Adult
MH  - Antibody Specificity
MH  - Aquaporin 4/immunology/metabolism
MH  - Brain/metabolism/*pathology
MH  - Brain Edema/metabolism/*pathology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - Neuromyelitis Optica/metabolism/*pathology
MH  - Recurrence
MH  - Retrospective Studies
MH  - Sjogren's Syndrome/metabolism/*pathology
MH  - Spinal Cord/metabolism/pathology
EDAT- 2009/07/25 09:00
MHDA- 2009/10/31 06:00
CRDT- 2009/07/24 09:00
PHST- 2009/07/24 09:00 [entrez]
PHST- 2009/07/25 09:00 [pubmed]
PHST- 2009/10/31 06:00 [medline]
AID - 1352458509106228 [pii]
AID - 10.1177/1352458509106228 [doi]
PST - ppublish
SO  - Mult Scler. 2009 Sep;15(9):1069-76. doi: 10.1177/1352458509106228. Epub 2009 Jul 
      22.