PMID- 19626358
OWN - NLM
STAT- MEDLINE
DCOM- 20100304
LR  - 20240418
IS  - 1436-6215 (Electronic)
IS  - 1436-6207 (Print)
IS  - 1436-6207 (Linking)
VI  - 49
IP  - 1
DP  - 2010 Feb
TI  - Comparison of free fructose and glucose to sucrose in the ability to cause fatty 
      liver.
PG  - 1-9
LID - 10.1007/s00394-009-0042-x [doi]
AB  - BACKGROUND: There is evidence that disaccharide sucrose produce a greater 
      increase in serum fructose and triglycerides (TGs) than the effect produced by 
      their equivalent monosaccharides, suggesting that long-term exposure to sucrose 
      or fructose + glucose could potentially result in different effects. AIM OF THE 
      STUDY: We studied the chronic effects of a combination of free fructose and 
      glucose relative to sucrose on rat liver. METHODS: Rats were fed either a 
      combination of 30% fructose and 30% glucose (FG) or 60% sucrose (S). Control rats 
      were fed normal rat chow (C). All rats were pair fed and were followed for 4 
      months. After killing, blood chemistries and liver tissue were examined. RESULTS: 
      Both FG-fed- and S-fed rats developed early features of metabolic syndrome when 
      compared with C. In addition, both diets induced hepatic alterations, including 
      variable increases in hepatic TG accumulation and fatty liver, an increase in 
      uric acid content in the liver, as well as an increase in hepatic levels of 
      monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha 
      (TNF-alpha) measured in liver homogenates. CONCLUSIONS: Diets containing 30% of 
      fructose either as free fructose and glucose, or as sucrose, induce metabolic 
      syndrome, intrahepatic accumulation of uric acid and TGs, increased MCP-1 and 
      TNF-alpha as well as fatty liver in rats. It will be relevant to determine 
      clinically whether pharmacological reduction in uric acid levels might have a 
      therapeutic advantage in the treatment of non-alcoholic fatty liver disease.
FAU - Sanchez-Lozada, Laura G
AU  - Sanchez-Lozada LG
AD  - Division of Nephrology, Hypertension and Transplantation, University of Florida, 
      Gainesville, FL, USA. lgsanchezlozada@gmail.com
FAU - Mu, Wei
AU  - Mu W
FAU - Roncal, Carlos
AU  - Roncal C
FAU - Sautin, Yuri Y
AU  - Sautin YY
FAU - Abdelmalek, Manal
AU  - Abdelmalek M
FAU - Reungjui, Sirirat
AU  - Reungjui S
FAU - Le, MyPhuong
AU  - Le M
FAU - Nakagawa, Takahiko
AU  - Nakagawa T
FAU - Lan, Hui Y
AU  - Lan HY
FAU - Yu, Xuequing
AU  - Yu X
FAU - Johnson, Richard J
AU  - Johnson RJ
LA  - eng
GR  - R01 HL068607/HL/NHLBI NIH HHS/United States
GR  - R01 HL068607-08/HL/NHLBI NIH HHS/United States
GR  - HL-68607/HL/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090722
PL  - Germany
TA  - Eur J Nutr
JT  - European journal of nutrition
JID - 100888704
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Sucrose)
RN  - 0 (Triglycerides)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 268B43MJ25 (Uric Acid)
RN  - 30237-26-4 (Fructose)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Body Fat Distribution
MH  - Chemokine CCL2/analysis
MH  - Dietary Carbohydrates/*administration & dosage
MH  - Dietary Sucrose/*administration & dosage
MH  - Energy Intake
MH  - Fatty Liver/*etiology/metabolism/pathology
MH  - Fructose/*administration & dosage
MH  - Glucose/*administration & dosage
MH  - Liver/chemistry
MH  - Male
MH  - Metabolic Syndrome/etiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Triglycerides/analysis/blood
MH  - Tumor Necrosis Factor-alpha/analysis
MH  - Uric Acid/analysis/blood
PMC - PMC2805058
MID - NIHMS149475
EDAT- 2009/07/25 09:00
MHDA- 2010/03/05 06:00
PMCR- 2010/02/01
CRDT- 2009/07/24 09:00
PHST- 2009/02/10 00:00 [received]
PHST- 2009/07/05 00:00 [accepted]
PHST- 2009/07/24 09:00 [entrez]
PHST- 2009/07/25 09:00 [pubmed]
PHST- 2010/03/05 06:00 [medline]
PHST- 2010/02/01 00:00 [pmc-release]
AID - 10.1007/s00394-009-0042-x [doi]
PST - ppublish
SO  - Eur J Nutr. 2010 Feb;49(1):1-9. doi: 10.1007/s00394-009-0042-x. Epub 2009 Jul 22.