PMID- 19626623
OWN - NLM
STAT- MEDLINE
DCOM- 20100217
LR  - 20131121
IS  - 1097-0339 (Electronic)
IS  - 1097-0339 (Linking)
VI  - 38
IP  - 1
DP  - 2010 Jan
TI  - Dysplastic cells in cytological cervical samples show a high incidence of 
      chromosomal abnormalities.
PG  - 28-33
LID - 10.1002/dc.21142 [doi]
AB  - Chromosomal abnormalities are frequent in most cervical cancers. Amplifications 
      of both the 3q26 (TERC) and 8q24 (MYC) loci have been shown to be prevalent in 
      both high-grade lesions and invasive cervical carcinoma. Most of these studies 
      have looked at either the histological sample or at the entire cytological 
      population of cells. We have developed a Papanicolaou (Pap) destaining method 
      that allows for the accurate analysis of individual cells that were previously 
      identified by cytopathology as dysplastic. The application of fluorescence in 
      situ hybridization (FISH) was then implemented to determine the chromosomal 
      status of the dysplastic cells in the samples and correlate the two events. 
      Chromosomal abnormality is over a thousand times more frequent in dysplastic 
      cells compared with their morphologically normal counterparts.
CI  - (c) 2009 Wiley-Liss, Inc.
FAU - Song, Minghao
AU  - Song M
AD  - Abbott Molecular, Inc., Des Plaines, Illinois 60018, USA.
FAU - Ruth, Adam
AU  - Ruth A
FAU - Policht, Frank A
AU  - Policht FA
FAU - Bubendorf, Lukas
AU  - Bubendorf L
FAU - Feichter, Georg
AU  - Feichter G
FAU - Kipp, Benjamin R
AU  - Kipp BR
FAU - Halling, Kevin C
AU  - Halling KC
FAU - Sokolova, Irina A
AU  - Sokolova IA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Diagn Cytopathol
JT  - Diagnostic cytopathology
JID - 8506895
SB  - IM
MH  - Carcinoma, Squamous Cell/pathology
MH  - Cervix Uteri/*pathology
MH  - *Chromosome Aberrations
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Papanicolaou Test
MH  - Vaginal Smears/*methods
EDAT- 2009/07/25 09:00
MHDA- 2010/02/18 06:00
CRDT- 2009/07/24 09:00
PHST- 2009/07/24 09:00 [entrez]
PHST- 2009/07/25 09:00 [pubmed]
PHST- 2010/02/18 06:00 [medline]
AID - 10.1002/dc.21142 [doi]
PST - ppublish
SO  - Diagn Cytopathol. 2010 Jan;38(1):28-33. doi: 10.1002/dc.21142.