PMID- 19626994
OWN - NLM
STAT- MEDLINE
DCOM- 20100401
LR  - 20090724
IS  - 1672-173X (Print)
IS  - 1672-173X (Linking)
VI  - 40
IP  - 3
DP  - 2009 May
TI  - [Study on the expression of BDNF in human gliomas].
PG  - 415-7
AB  - OBJECTIVE: To investigate the expression of brain-derived neurotrophic factors 
      (BDNF) in gliomas of human, and explore the relation between BDNF and pathologic 
      grading and tumorigenesis of gliomas. METHODS: Immunohistochemistry (SP) and 
      Western blot were applied to evaluate the expression of BDNF in 5 cases of normal 
      controls and 20 cases of gliomas from different pathologic grading. RESULTS: The 
      expression of BDNF was observed mainly occurred in the cytoplasm of both normal 
      brain tissues and gliomas. Western blot analysis showed that the expression level 
      of BDNF in gliomas was significantly higher than that of normal controls 
      (P<0.05), and a gradually increased expression of BDNF in vary pathologic grading 
      (grade I, II, III, IV) gliomas was also observed. CONCLUSION: The expression of 
      BDNF in gliomas of human was greatly upregulated, indicating BDNF may play an 
      important role in the tumorigenesis of gliomas, and relate with pathologic 
      grading.
FAU - Yan, Qi
AU  - Yan Q
AD  - Department of Minimally Invasive Neurosurgery, No 1 Affiliated Hospital, Kunming 
      Medical College, Kunming 650031, China.
FAU - Yu, Hua-lin
AU  - Yu HL
FAU - Li, Jing-tao
AU  - Li JT
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Sichuan Da Xue Xue Bao Yi Xue Ban
JT  - Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical 
      science edition
JID - 101162609
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Astrocytoma/*metabolism/pathology
MH  - Brain Neoplasms/*metabolism/pathology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Case-Control Studies
MH  - Female
MH  - Glioma/*metabolism/*pathology
MH  - Humans
MH  - Immunochemistry
MH  - Male
MH  - Middle Aged
EDAT- 2009/07/25 09:00
MHDA- 2010/04/02 06:00
CRDT- 2009/07/25 09:00
PHST- 2009/07/25 09:00 [entrez]
PHST- 2009/07/25 09:00 [pubmed]
PHST- 2010/04/02 06:00 [medline]
PST - ppublish
SO  - Sichuan Da Xue Xue Bao Yi Xue Ban. 2009 May;40(3):415-7.