PMID- 19627379
OWN - NLM
STAT- MEDLINE
DCOM- 20101110
LR  - 20211020
IS  - 1365-2605 (Electronic)
IS  - 0105-6263 (Print)
IS  - 0105-6263 (Linking)
VI  - 33
IP  - 4
DP  - 2010 Aug 1
TI  - Effect modification of endocrine disruptors and testicular germ cell tumour risk 
      by hormone-metabolizing genes.
PG  - 588-96
LID - 10.1111/j.1365-2605.2009.00975.x [doi]
AB  - It has been hypothesized that the increased prevalence of testicular germ cell 
      tumours (TGCT) may be attributable to endocrine disrupting chemicals, such as 
      persistent organic pollutants (POPs); these may be modulated by 
      hormone-metabolizing enzymes. Using data from 568 cases and 698 controls enrolled 
      in the US Servicemen's Testicular Tumor Environmental and Endocrine Determinants 
      Study, we examined associations between TGCT and POPs, including 
      p,p'-dichlorodiphenyldichloroethylene, chlordane-related compounds and 
      polychlorinated biphenyls (PCBs), modified by polymorphisms in five 
      hormone-metabolizing genes (CYP17A1, CYP1A1, HSD17B1, HSD17B4 and AR). Odds 
      ratios (OR) and 95% confidence intervals (CI) were estimated using logistic 
      regression models that stratified associations of POP exposure and TGCT risk by 
      genotype. Two polymorphisms in CYP1A1, rs1456432 and rs7495708, modified the 
      association between trans-nonachlor and total chlordanes and TGCT risk. Among men 
      with a minor allele for rs1456432, those with the highest quartiles had an 
      increased risk of TGCT (OR = 1.90, 95% CI, 1.01-3.56) compared with those with 
      the lowest; there was no increased risk among men with the homozygous major 
      allele genotype (p-interactions = 0.024). Similar results were seen for 
      rs7495708. HSD17B4 rs384346 modified the associations between TGCT risk and 
      PCB-118 and PCB-138 concentrations: the 45-55% reductions in TGCT risk for men 
      with the highest quartiles compared with the lowest quartiles were only present 
      in those who had a major homozygous allele genotype (p-interactions < 0.04). 
      Thus, there are suggestions that certain CYP1A1 and HSD17B4 polymorphisms may 
      modify the associations between POPs and TGCT risk. With false discovery rate 
      values >0.2, however, caution is advisable when interpreting the findings of this 
      study.
FAU - Chia, V M
AU  - Chia VM
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 
      Rockville, Maryland 20892-7234, USA.
FAU - Li, Y
AU  - Li Y
FAU - Quraishi, S M
AU  - Quraishi SM
FAU - Graubard, B I
AU  - Graubard BI
FAU - Figueroa, J D
AU  - Figueroa JD
FAU - Weber, J-P
AU  - Weber JP
FAU - Chanock, S J
AU  - Chanock SJ
FAU - Rubertone, M V
AU  - Rubertone MV
FAU - Erickson, R L
AU  - Erickson RL
FAU - McGlynn, K A
AU  - McGlynn KA
LA  - eng
GR  - Z01 CP010126-13/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20090720
PL  - England
TA  - Int J Androl
JT  - International journal of andrology
JID - 8000141
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Receptors, Androgen)
RN  - 12789-03-6 (Chlordan)
RN  - 3734-49-4 (nonachlor)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - EC 1.1.- (17-Hydroxysteroid Dehydrogenases)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1A1)
RN  - EC 4.2.1.- (Hydro-Lyases)
RN  - EC 4.2.1.107 (Peroxisomal Multifunctional Protein-2)
RN  - EC 4.2.1.119 (HSD17B4 protein, human)
SB  - IM
MH  - 17-Hydroxysteroid Dehydrogenases/*genetics/metabolism
MH  - Chlordan/metabolism
MH  - Cytochrome P-450 CYP1A1/*genetics/metabolism
MH  - Endocrine Disruptors/*metabolism
MH  - Humans
MH  - Hydro-Lyases/*genetics/metabolism
MH  - Hydrocarbons, Chlorinated/metabolism
MH  - Male
MH  - Neoplasms, Germ Cell and Embryonal/*genetics
MH  - Peroxisomal Multifunctional Protein-2
MH  - Polychlorinated Biphenyls/metabolism/toxicity
MH  - Receptors, Androgen/genetics
MH  - Testicular Neoplasms/etiology
PMC - PMC2891172
MID - NIHMS150448
EDAT- 2009/07/25 09:00
MHDA- 2010/11/11 06:00
PMCR- 2011/08/01
CRDT- 2009/07/25 09:00
PHST- 2009/07/25 09:00 [entrez]
PHST- 2009/07/25 09:00 [pubmed]
PHST- 2010/11/11 06:00 [medline]
PHST- 2011/08/01 00:00 [pmc-release]
AID - IJA975 [pii]
AID - 10.1111/j.1365-2605.2009.00975.x [doi]
PST - ppublish
SO  - Int J Androl. 2010 Aug 1;33(4):588-96. doi: 10.1111/j.1365-2605.2009.00975.x. 
      Epub 2009 Jul 20.