PMID- 19627765
OWN - NLM
STAT- MEDLINE
DCOM- 20110201
LR  - 20111206
IS  - 1579-2021 (Electronic)
IS  - 1575-0922 (Linking)
VI  - 56 Suppl 2
DP  - 2009 Apr
TI  - [Genetic profile of gastroenteropancreatic neuroendocrine tumors].
PG  - 16-9
LID - 10.1016/S1575-0922(09)70860-5 [doi]
AB  - Gastroenteropancreatic neuroendocrine tumors are relatively rare neoplasms but 
      their incidence has significantly increased in the last 30 years. These tumors 
      are usually sporadic but can also occur as part of certain endocrine tumor 
      susceptibility syndromes such as multiple endocrine neoplasia type1 (MEN1) and 
      von Hippel Lindau disease. The genetic abnormalities associated with the 
      development or progression of these tumors depend on the site of origin and 
      suggest multiple gene involvement. Knowledge of this genetic complex has been 
      gained from a variety of approaches such as comparative genomic hybridization, 
      loss of heterozygosity and DNA microarray analysis. These genetic studies 
      indicate that pancreatic endocrine tumors frequently harbor mutations in the MEN1 
      gene, among others, and that carcinoid tumors, in contrast, show more alterations 
      on chromosome 18. Nevertheless, the molecular pathogenesis of 
      gastroenteropancreatic neuroendocrine tumors remains to be fully elucidated, 
      mainly because the data refer to small and heterogeneous tumor series.
FAU - Cabezas Agricola, Jose M
AU  - Cabezas Agricola JM
AD  - Servicio de Endocrinologia y Nutricion, Complejo Hospitalario Universitario de 
      Santiago (C.H.U.S.), Santiago de Compostela, Espana. 
      jose.manuel.cabezas.agricola@sergas.es
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Perfil genetico de los tumores neuroendocrinos gastroenteropancreaticos.
DEP - 20090518
PL  - Spain
TA  - Endocrinol Nutr
JT  - Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y 
      Nutricion
JID - 100886482
RN  - Gastro-enteropancreatic neuroendocrine tumor
SB  - IM
MH  - Humans
MH  - *Intestinal Neoplasms/genetics
MH  - *Neuroendocrine Tumors/genetics
MH  - *Pancreatic Neoplasms/genetics
MH  - *Stomach Neoplasms/genetics
EDAT- 2009/07/25 09:00
MHDA- 2011/02/02 06:00
CRDT- 2009/07/25 09:00
PHST- 2009/07/25 09:00 [entrez]
PHST- 2009/07/25 09:00 [pubmed]
PHST- 2011/02/02 06:00 [medline]
AID - S1575-0922(09)70860-5 [pii]
AID - 10.1016/S1575-0922(09)70860-5 [doi]
PST - ppublish
SO  - Endocrinol Nutr. 2009 Apr;56 Suppl 2:16-9. doi: 10.1016/S1575-0922(09)70860-5. 
      Epub 2009 May 18.