PMID- 19628486
OWN - NLM
STAT- MEDLINE
DCOM- 20091026
LR  - 20220318
IS  - 1471-6771 (Electronic)
IS  - 0007-0912 (Linking)
VI  - 103
IP  - 4
DP  - 2009 Oct
TI  - Effect of short-term exercise training on aerobic fitness in patients with 
      abdominal aortic aneurysms: a pilot study.
PG  - 505-10
LID - 10.1093/bja/aep205 [doi]
AB  - BACKGROUND: Patients with abdominal aortic aneurysms (AAA) represent a high-risk 
      surgical group. Despite medical optimization and radiological stenting 
      interventions, mortality remains high and it is difficult to improve fitness. The 
      aim of this pilot study was to evaluate the effect of a 6 week, supervised 
      exercise programme (30 min continuous moderate intensity cycle ergometry, twice 
      weekly) on anaerobic threshold (AT) in subjects with AAA. METHODS: Thirty 
      participants with an AAA under surveillance were randomized to either the 
      supervised exercise intervention (n=20) or a usual care control group (n=10). AT 
      was measured using cardiopulmonary exercise testing, at baseline (AT1), week 5 
      (AT2), and week 7 (AT3). The change in AT (AT3-AT1) between the groups was 
      compared using a mixed model ancova, providing the mean effect together with the 
      standard deviation (sd) for individual patient responses to the intervention. The 
      minimum clinically important difference (MCID) was defined as an improvement in 
      AT of 2 ml O(2) kg(-1) min(-1). RESULTS: Of the 30 participants recruited, 17 of 
      20 (exercise) and eight of 10 (control) completed the study. The AT in the 
      intervention group increased by 10% (equivalent to 1.1 ml O(2) kg(-1) min(-1)) 
      compared with the control (90% confidence interval 4-16%; P=0.007). The sd for 
      the individual patient responses to the intervention was 8%. The estimated number 
      needed to treat (NNT) for benefit was 5 patients. CONCLUSIONS: The small mean 
      benefit was lower than the MCID. However, the marked variability in the 
      individual patient responses revealed that a proportion of patients did benefit 
      clinically, with an estimated NNT of 5.
FAU - Kothmann, E
AU  - Kothmann E
AD  - Department of Anaesthesia, James Cook University Hospital, Middlesbrough, UK.
FAU - Batterham, A M
AU  - Batterham AM
FAU - Owen, S J
AU  - Owen SJ
FAU - Turley, A J
AU  - Turley AJ
FAU - Cheesman, M
AU  - Cheesman M
FAU - Parry, A
AU  - Parry A
FAU - Danjoux, G
AU  - Danjoux G
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20090723
PL  - England
TA  - Br J Anaesth
JT  - British journal of anaesthesia
JID - 0372541
SB  - IM
CIN - Br J Anaesth. 2010 Feb;104(2):265-6; author reply 266-7. PMID: 20086068
MH  - Aged
MH  - Aortic Aneurysm, Abdominal/physiopathology/*rehabilitation
MH  - Exercise Test
MH  - Exercise Therapy/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Physical Fitness
MH  - Pilot Projects
MH  - Prospective Studies
MH  - Treatment Outcome
EDAT- 2009/07/25 09:00
MHDA- 2009/10/27 06:00
CRDT- 2009/07/25 09:00
PHST- 2009/07/25 09:00 [entrez]
PHST- 2009/07/25 09:00 [pubmed]
PHST- 2009/10/27 06:00 [medline]
AID - S0007-0912(17)33938-7 [pii]
AID - 10.1093/bja/aep205 [doi]
PST - ppublish
SO  - Br J Anaesth. 2009 Oct;103(4):505-10. doi: 10.1093/bja/aep205. Epub 2009 Jul 23.