PMID- 19628494
OWN - NLM
STAT- MEDLINE
DCOM- 20091214
LR  - 20091126
IS  - 1468-2079 (Electronic)
IS  - 0007-1161 (Linking)
VI  - 93
IP  - 12
DP  - 2009 Dec
TI  - Pattern electroretinography of larger stimulus field size and spectral-domain 
      optical coherence tomography in patients with Stargardt disease.
PG  - 1600-5
LID - 10.1136/bjo.2009.158725 [doi]
AB  - AIMS: To investigate the importance of a larger stimulus field for pattern 
      electroretinography (PERG) in evaluating macular function in Stargardt disease, 
      and to determine the relationship between PERG and spectral-domain optical 
      coherence tomography (SD-OCT). METHODS: In this prospective cross-sectional 
      study, PERG from standard (12 degrees x 16 degrees ) and larger (24 degrees x 32 
      degrees ) stimulus fields and SD-OCT were recorded in 18 patients with 
      genetically confirmed Stargardt disease, and in 18 control subjects. RESULTS: A 
      PERG P50 response to the larger stimulus field was detectable in 86% of eyes, 
      with a mean P50 amplitude of 2.3 microV, compared with 22% and 1.0 muV for the 
      standard stimulus field. The specificity and sensitivity of PERG to the standard 
      stimulus field were greater than for the larger field. For both PERG P50 and N95, 
      the differences in their amplitudes between the standard and larger stimulus 
      fields correlated significantly with visual acuity and SD-OCT parameters. 
      CONCLUSION: The higher sensitivity and specificity of PERG to the standard 
      stimulus field provide detection of early maculopathy in Stargardt disease, while 
      PERG with the larger stimulus field allows for longer follow-up. The PERG 
      amplitude for the larger stimulus field correlated with severity of transverse 
      photoreceptor loss in SD-OCT. These methods are complementary for evaluation of 
      progression of photoreceptor damage in patients with Stargardt disease.
FAU - Lenassi, E
AU  - Lenassi E
AD  - Eye Hospital, University Medical Centre Ljubljana, Grabloviceva 46, SI-1000 
      Ljubljana, Slovenia.
FAU - Jarc-Vidmar, M
AU  - Jarc-Vidmar M
FAU - Glavac, D
AU  - Glavac D
FAU - Hawlina, M
AU  - Hawlina M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090723
PL  - England
TA  - Br J Ophthalmol
JT  - The British journal of ophthalmology
JID - 0421041
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Electroretinography/methods
MH  - Eye Diseases, Hereditary/pathology/*physiopathology
MH  - Female
MH  - Humans
MH  - Macula Lutea/*physiopathology
MH  - Macular Degeneration/pathology/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Retina/pathology
MH  - Sensitivity and Specificity
MH  - Tomography, Optical Coherence
MH  - Visual Acuity
MH  - Visual Fields
MH  - Young Adult
EDAT- 2009/07/25 09:00
MHDA- 2009/12/16 06:00
CRDT- 2009/07/25 09:00
PHST- 2009/07/25 09:00 [entrez]
PHST- 2009/07/25 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
AID - bjo.2009.158725 [pii]
AID - 10.1136/bjo.2009.158725 [doi]
PST - ppublish
SO  - Br J Ophthalmol. 2009 Dec;93(12):1600-5. doi: 10.1136/bjo.2009.158725. Epub 2009 
      Jul 23.