PMID- 19628765
OWN - NLM
STAT- MEDLINE
DCOM- 20091027
LR  - 20231213
IS  - 1525-2191 (Electronic)
IS  - 0002-9440 (Print)
IS  - 0002-9440 (Linking)
VI  - 175
IP  - 2
DP  - 2009 Aug
TI  - Active uptake of dendritic cell-derived exovesicles by epithelial cells induces 
      the release of inflammatory mediators through a TNF-alpha-mediated pathway.
PG  - 696-705
LID - 10.2353/ajpath.2009.080716 [doi]
AB  - Dendritic cells (DCs) can release hundreds of membrane vesicles, called 
      exovesicles, which are able to activate resting DCs and distribute antigen. Here, 
      we examined the role of mature DC-derived exovesicles in innate and adaptive 
      immunity, in particular their capacity to activate epithelial cells. Our analysis 
      of exovesicle contents showed that exovesicles contain major histocompatibility 
      complex-II, CD40, and CD83 molecules in addition to tumor necrosis factor (TNF) 
      receptors, TNFRI and TNFRII, and are important carriers of TNF-alpha. These 
      exovesicles are rapidly internalized by epithelial cells, inducing the release of 
      cytokines and chemokines, but do not transfer an alloantigen-presenting capacity 
      to epithelial cells. Part of this activation appears to involve the 
      TNF-alpha-mediated pathway, highlighting the key role of DC-derived exovesicles, 
      not only in adaptive immunity, but also in innate immunity by triggering innate 
      immune responses and activating neighboring epithelial cells to release cytokines 
      and chemokines, thereby amplifying the magnitude of the innate immune response.
FAU - Obregon, Carolina
AU  - Obregon C
AD  - Medecin chef, Service de pneumologie, CHUV, 1011 Lausanne. Switzerland.
FAU - Rothen-Rutishauser, Barbara
AU  - Rothen-Rutishauser B
FAU - Gerber, Peter
AU  - Gerber P
FAU - Gehr, Peter
AU  - Gehr P
FAU - Nicod, Laurent P
AU  - Nicod LP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090723
PL  - United States
TA  - Am J Pathol
JT  - The American journal of pathology
JID - 0370502
RN  - 0 (Antigens, CD)
RN  - 0 (CD40 Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Immunoglobulins)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Antigens, CD/metabolism
MH  - CD40 Antigens/metabolism
MH  - Dendritic Cells/*immunology/metabolism
MH  - Endocytosis/*immunology
MH  - Epithelial Cells/*immunology
MH  - Exosomes/*metabolism
MH  - Histocompatibility Antigens Class II/metabolism
MH  - Humans
MH  - Immunoglobulins/metabolism
MH  - Inflammation Mediators/*metabolism
MH  - Membrane Glycoproteins/metabolism
MH  - Tumor Necrosis Factor-alpha/*metabolism
MH  - CD83 Antigen
PMC - PMC2715287
EDAT- 2009/07/25 09:00
MHDA- 2009/10/29 06:00
PMCR- 2010/08/01
CRDT- 2009/07/25 09:00
PHST- 2009/07/25 09:00 [entrez]
PHST- 2009/07/25 09:00 [pubmed]
PHST- 2009/10/29 06:00 [medline]
PHST- 2010/08/01 00:00 [pmc-release]
AID - S0002-9440(10)60582-2 [pii]
AID - 10.2353/ajpath.2009.080716 [doi]
PST - ppublish
SO  - Am J Pathol. 2009 Aug;175(2):696-705. doi: 10.2353/ajpath.2009.080716. Epub 2009 
      Jul 23.