PMID- 19629052
OWN - NLM
STAT- MEDLINE
DCOM- 20100222
LR  - 20220309
IS  - 1930-739X (Electronic)
IS  - 1930-7381 (Linking)
VI  - 18
IP  - 2
DP  - 2010 Feb
TI  - Neural mechanisms associated with food motivation in obese and healthy weight 
      adults.
PG  - 254-60
LID - 10.1038/oby.2009.220 [doi]
AB  - One out of three adults in the United States is clinically obese. Excess food 
      intake is associated with food motivation, which has been found to be higher in 
      obese compared to healthy weight (HW) individuals. Little is known, however, 
      regarding the neural mechanisms associated with food motivation in obese compared 
      to HW adults. The current study used functional magnetic resonance imaging (fMRI) 
      to examine changes in the hemodynamic response in obese and HW adults while they 
      viewed food and nonfood images in premeal and postmeal states. During the premeal 
      condition, obese participants showed increased activation, compared to HW 
      participants, in anterior cingulate cortex (ACC) and medial prefrontal cortex 
      (MPFC). Moreover, in the obese group, self-report measures of disinhibition were 
      negatively correlated with premeal ACC activations and self-report measures of 
      hunger were positively correlated with premeal MPFC activations. During the 
      postmeal condition, obese participants also showed greater activation than HW 
      participants in the MPFC. These results indicate that brain function associated 
      with food motivation differs in obese and HW adults and may have implications for 
      understanding brain mechanisms contributing to overeating and obesity, and 
      variability in response to diet interventions.
FAU - Martin, Laura E
AU  - Martin LE
AD  - Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, 
      Kansas, USA.
FAU - Holsen, Laura M
AU  - Holsen LM
FAU - Chambers, Rebecca J
AU  - Chambers RJ
FAU - Bruce, Amanda S
AU  - Bruce AS
FAU - Brooks, William M
AU  - Brooks WM
FAU - Zarcone, Jennifer R
AU  - Zarcone JR
FAU - Butler, Merlin G
AU  - Butler MG
FAU - Savage, Cary R
AU  - Savage CR
LA  - eng
GR  - AG026482/AG/NIA NIH HHS/United States
GR  - HD02528/HD/NICHD NIH HHS/United States
GR  - NS039123/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090723
PL  - United States
TA  - Obesity (Silver Spring)
JT  - Obesity (Silver Spring, Md.)
JID - 101264860
SB  - IM
MH  - Brain Mapping/methods
MH  - Case-Control Studies
MH  - *Cerebrovascular Circulation
MH  - Fasting
MH  - *Feeding Behavior
MH  - Female
MH  - Humans
MH  - Hunger
MH  - Limbic System/blood supply/*physiopathology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - *Motivation
MH  - Obesity/*physiopathology/*psychology
MH  - Photic Stimulation
MH  - Postprandial Period
MH  - Prefrontal Cortex/blood supply/*physiopathology
EDAT- 2009/07/25 09:00
MHDA- 2010/02/23 06:00
CRDT- 2009/07/25 09:00
PHST- 2009/07/25 09:00 [entrez]
PHST- 2009/07/25 09:00 [pubmed]
PHST- 2010/02/23 06:00 [medline]
AID - oby2009220 [pii]
AID - 10.1038/oby.2009.220 [doi]
PST - ppublish
SO  - Obesity (Silver Spring). 2010 Feb;18(2):254-60. doi: 10.1038/oby.2009.220. Epub 
      2009 Jul 23.