PMID- 19630790
OWN - NLM
STAT- MEDLINE
DCOM- 20091201
LR  - 20230829
IS  - 1538-7836 (Electronic)
IS  - 1538-7933 (Print)
IS  - 1538-7836 (Linking)
VI  - 7 Suppl 1
IP  - Suppl 1
DP  - 2009 Jul
TI  - Tissue plasminogen activator-mediated PDGF signaling and neurovascular coupling 
      in stroke.
PG  - 155-8
LID - 10.1111/j.1538-7836.2009.03402.x [doi]
AB  - The use of tissue plasminogen activator (tPA) as a thrombolytic treatment in 
      ischemic stroke is limited largely due to concerns for hemorrhagic complications. 
      The underlying mechanisms are still unknown, but evidence is beginning to emerge 
      that tPA interacts with key regulators of the neurovascular unit (NVU), and that 
      these interactions may contribute to the undesirable side effects associated with 
      the use of tPA in ischemic stroke. Understanding these connections and tPA's 
      normal function within the NVU may offer new insights into future therapeutic 
      approaches.
FAU - Su, E J
AU  - Su EJ
AD  - Department of Internal Medicine, University of Michigan Medical School, MI 48109, 
      USA.
FAU - Fredriksson, L
AU  - Fredriksson L
FAU - Schielke, G P
AU  - Schielke GP
FAU - Eriksson, U
AU  - Eriksson U
FAU - Lawrence, D A
AU  - Lawrence DA
LA  - eng
GR  - HL-89407/HL/NHLBI NIH HHS/United States
GR  - P01 HL054710/HL/NHLBI NIH HHS/United States
GR  - P01 HL054710-130006/HL/NHLBI NIH HHS/United States
GR  - R01 HL055374-14/HL/NHLBI NIH HHS/United States
GR  - HL-54710/HL/NHLBI NIH HHS/United States
GR  - P01 HL054710-140006/HL/NHLBI NIH HHS/United States
GR  - R01 HL055374/HL/NHLBI NIH HHS/United States
GR  - P01 HL089407/HL/NHLBI NIH HHS/United States
GR  - R01 HL055374-13/HL/NHLBI NIH HHS/United States
GR  - R01 HL055374-15/HL/NHLBI NIH HHS/United States
GR  - P01 HL054710-120006/HL/NHLBI NIH HHS/United States
GR  - HL-55374/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - J Thromb Haemost
JT  - Journal of thrombosis and haemostasis : JTH
JID - 101170508
RN  - 0 (Platelet-Derived Growth Factor)
RN  - EC 3.4.21.68 (Tissue Plasminogen Activator)
SB  - IM
MH  - Blood Vessels/innervation
MH  - Cerebrovascular Circulation
MH  - Humans
MH  - Platelet-Derived Growth Factor/*metabolism
MH  - Signal Transduction
MH  - Stroke/*drug therapy
MH  - Tissue Plasminogen Activator/*pharmacology/therapeutic use
PMC - PMC2912222
MID - NIHMS220042
COIS- Disclosure and Conflict of Interests: The authors state they have no conflict of 
      interest.
EDAT- 2009/07/28 09:00
MHDA- 2009/12/16 06:00
PMCR- 2010/07/29
CRDT- 2009/07/28 09:00
PHST- 2009/07/28 09:00 [entrez]
PHST- 2009/07/28 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
PHST- 2010/07/29 00:00 [pmc-release]
AID - S1538-7836(22)17421-0 [pii]
AID - 10.1111/j.1538-7836.2009.03402.x [doi]
PST - ppublish
SO  - J Thromb Haemost. 2009 Jul;7 Suppl 1(Suppl 1):155-8. doi: 
      10.1111/j.1538-7836.2009.03402.x.