PMID- 19631945
OWN - NLM
STAT- MEDLINE
DCOM- 20100225
LR  - 20091209
IS  - 1532-3129 (Electronic)
IS  - 0021-9975 (Linking)
VI  - 142
IP  - 1
DP  - 2010 Jan
TI  - Immunohistochemical detection of aetiological agents of proliferative and 
      necrotizing pneumonia in italian pigs.
PG  - 74-8
LID - 10.1016/j.jcpa.2009.06.003 [doi]
AB  - Proliferative and necrotizing pneumonia (PNP) is a form of interstitial pneumonia 
      that occurs in weaning and post-weaning pigs. PNP is characterized by hypertrophy 
      and hyperplasia of type II pneumocytes and coagulative necrosis and granular 
      debris within alveolar spaces. Canadian and European studies suggest that the 
      porcine reproductive and respiratory syndrome virus (PRRSV) and porcine 
      circovirus type 2 (PCV2) are the main causes of the disease, but Aujezsky's 
      disease virus (ADV) and swine influenza virus (SIV) have also been considered as 
      potential aetiological agents. An immunohistochemical study was carried out on 
      the lungs of 28 Italian pigs with PNP in order to evaluate the role of PRRSV, 
      PCV2 and ADV in PNP lesions. PRRSV infection was identified in the lungs of 11 
      pigs, PCV2 in the lungs of four pigs and coinfection with both viruses in the 
      lungs of eight pigs. Neither virus was detected in the lungs of the remaining 
      five pigs. ADV antigen was not detected in any sample. The principle aetiological 
      agent of PNP in Italy therefore appears to be PRRSV. Coinfection with PRRSV and 
      PCV2 is characterized by more severe microscopical changes in affected lungs.
FAU - Morandi, F
AU  - Morandi F
AD  - Department of Veterinary Public Health and Animal Pathology, School of Veterinary 
      Medicine, Bologna University, Italy.
FAU - Ostanello, F
AU  - Ostanello F
FAU - Fusaro, L
AU  - Fusaro L
FAU - Bacci, B
AU  - Bacci B
FAU - Nigrelli, A
AU  - Nigrelli A
FAU - Alborali, L
AU  - Alborali L
FAU - Dottori, M
AU  - Dottori M
FAU - Vezzoli, F
AU  - Vezzoli F
FAU - Barigazzi, G
AU  - Barigazzi G
FAU - Fiorentini, L
AU  - Fiorentini L
FAU - Sala, V
AU  - Sala V
FAU - Leotti, G
AU  - Leotti G
FAU - Joisel, F
AU  - Joisel F
FAU - Sarli, G
AU  - Sarli G
LA  - eng
PT  - Journal Article
DEP - 20090724
PL  - England
TA  - J Comp Pathol
JT  - Journal of comparative pathology
JID - 0102444
RN  - 0 (Antigens, Viral)
SB  - IM
MH  - Animals
MH  - Antigens, Viral/biosynthesis
MH  - Circovirus/isolation & purification
MH  - Herpesvirus 1, Suid/isolation & purification
MH  - Immunohistochemistry
MH  - Italy
MH  - Lung Diseases, Interstitial/*microbiology/pathology/*veterinary
MH  - Orthomyxoviridae/isolation & purification
MH  - Porcine respiratory and reproductive syndrome virus/isolation & purification
MH  - Swine
MH  - Swine Diseases/*microbiology/pathology
EDAT- 2009/07/28 09:00
MHDA- 2010/02/26 06:00
CRDT- 2009/07/28 09:00
PHST- 2009/01/14 00:00 [received]
PHST- 2009/05/14 00:00 [revised]
PHST- 2009/06/10 00:00 [accepted]
PHST- 2009/07/28 09:00 [entrez]
PHST- 2009/07/28 09:00 [pubmed]
PHST- 2010/02/26 06:00 [medline]
AID - S0021-9975(09)00080-2 [pii]
AID - 10.1016/j.jcpa.2009.06.003 [doi]
PST - ppublish
SO  - J Comp Pathol. 2010 Jan;142(1):74-8. doi: 10.1016/j.jcpa.2009.06.003. Epub 2009 
      Jul 24.