PMID- 19632149
OWN - NLM
STAT- MEDLINE
DCOM- 20090828
LR  - 20191210
IS  - 1872-8952 (Electronic)
IS  - 1388-2457 (Linking)
VI  - 120
IP  - 8
DP  - 2009 Aug
TI  - Decreased spatial frequency sensitivities for processing faces in male patients 
      with chronic schizophrenia.
PG  - 1525-33
LID - 10.1016/j.clinph.2009.06.016 [doi]
AB  - OBJECTIVE: Schizophrenia impairs early visual cognitive processing. Low and high 
      spatial frequency (LSF, HSF) visual information are differentially processed in 
      humans. We investigated whether electrophysiological abnormalities exist in 
      visual processing for spatial frequency (SF)-filtered neutral/emotional faces in 
      schizophrenics. METHODS: Subjects consisted of 16 male chronic schizophrenics and 
      23 controls. Event-related potentials (ERPs) to SF-filtered (LSF or HSF) and 
      unfiltered (broad SF; BSF) pictures of neutral, happy, and fearful faces were 
      recorded at 20 scalp sites. The relationships between the P100 (P1)/N170 
      amplitudes and the Global Assessment of Functioning (GAF) scores in patients were 
      also evaluated. RESULTS: For the P1 amplitudes at O1/O2, controls exhibited a 
      significant LSF>BSF difference, while schizophrenics showed no LSF>BSF 
      difference. For the N170 amplitudes at T5/T6, controls revealed a significant 
      HSF>BSF difference, while schizophrenics showed no such difference. For the P1 
      latencies, controls but not schizophrenics showed a significant difference 
      (LSF>BSF=HSF). For the N170 latencies, no significant SF differentiation was 
      found between the two groups. For both P1 and N170 amplitudes, no significant 
      effects of facial expressions were observed in controls and patients regardless 
      of SFs. There were significant negative correlations between the GAF scores and 
      the N170 amplitudes to BSF faces in schizophrenics, but not for P1 amplitudes. 
      CONCLUSIONS: Schizophrenics showed abnormal P1 and N170 responses to SF changes 
      in faces, thus indicating decreased SF sensitivities for processing of faces. 
      SIGNIFICANCE: Abnormal early visual processing may underlie some of the deficits 
      associated with face recognition in schizophrenia.
FAU - Obayashi, Choji
AU  - Obayashi C
AD  - Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu 
      University, Higashi-ku, Fukuoka, Japan.
FAU - Nakashima, Taisuke
AU  - Nakashima T
FAU - Onitsuka, Toshiaki
AU  - Onitsuka T
FAU - Maekawa, Toshihiko
AU  - Maekawa T
FAU - Hirano, Yoji
AU  - Hirano Y
FAU - Hirano, Shogo
AU  - Hirano S
FAU - Oribe, Naoya
AU  - Oribe N
FAU - Kaneko, Kunihiko
AU  - Kaneko K
FAU - Kanba, Shigenobu
AU  - Kanba S
FAU - Tobimatsu, Shozo
AU  - Tobimatsu S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090724
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Discrimination, Psychological/*physiology
MH  - Electroencephalography/methods
MH  - Evoked Potentials/*physiology
MH  - *Facial Expression
MH  - Humans
MH  - Male
MH  - Pattern Recognition, Visual/*physiology
MH  - Photic Stimulation/methods
MH  - Reaction Time/physiology
MH  - Schizophrenia/*physiopathology
MH  - Statistics as Topic
MH  - Young Adult
EDAT- 2009/07/28 09:00
MHDA- 2009/08/29 09:00
CRDT- 2009/07/28 09:00
PHST- 2008/10/24 00:00 [received]
PHST- 2009/05/27 00:00 [revised]
PHST- 2009/06/20 00:00 [accepted]
PHST- 2009/07/28 09:00 [entrez]
PHST- 2009/07/28 09:00 [pubmed]
PHST- 2009/08/29 09:00 [medline]
AID - S1388-2457(09)00398-8 [pii]
AID - 10.1016/j.clinph.2009.06.016 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2009 Aug;120(8):1525-33. doi: 10.1016/j.clinph.2009.06.016. 
      Epub 2009 Jul 24.