PMID- 19632523
OWN - NLM
STAT- MEDLINE
DCOM- 20110310
LR  - 20131121
IS  - 1876-4738 (Electronic)
IS  - 0914-5087 (Linking)
VI  - 54
IP  - 1
DP  - 2009 Aug
TI  - Effects of gastric medicines on gastroduodenal injury in patients with stable 
      angina during antiplatelet therapy.
PG  - 71-5
LID - 10.1016/j.jjcc.2009.04.002 [doi]
AB  - BACKGROUND: The aim of this study was to examine the effects of gastric medicines 
      on gastroduodenal injury during antiplatelet therapy after coronary intervention. 
      METHODS: A total of 501 patients were enrolled and as dual antiplatelet therapy, 
      aspirin and thienopyridine were administered. Patients were divided into four 
      groups: histamine H2-receptor antagonists (H2RA); proton pump inhibitors (PPI); 
      other gastromucosal protective agents (GMP); or nothing (None), and follow-up 
      lasted 8-20 months. RESULTS: H2RA were prescribed in 212 cases (42%), PPI in 150 
      (30%), GMP in 56 (11%), and None in 83 (17%). Significant findings by endoscopy 
      were recognized in 18 cases and upper gastrointestinal bleeding requiring 
      hospitalization occurred in 7 patients (1.4%; H2RA in 4, GMP in 2, and None in 
      1). There were no gastrointestinal injuries in the PPI group. To minimize the 
      effect of selection bias on gastroduodenal lesions, the propensity score analysis 
      for clinical characteristics was used. The results of propensity score matching 
      showed that administration of PPI reduced the incidence of gastrointestinal 
      lesions compared with that of the non-PPI group. CONCLUSION: Administration of 
      PPI reduced the incidence of gastrointestinal lesions compared with that of the 
      non-PPI group.
FAU - Hokimoto, Seiji
AU  - Hokimoto S
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kumamoto University, 1-1-1, Honjo, Kumamoto 860-8556, Japan. 
      aogimoto@m.ehime-u.ac.jp
FAU - Matsui, Kunihiko
AU  - Matsui K
FAU - Oshima, Shuichi
AU  - Oshima S
FAU - Noda, Katsuo
AU  - Noda K
FAU - Kaikita, Koichi
AU  - Kaikita K
FAU - Sumida, Hitoshi
AU  - Sumida H
FAU - Sugiyama, Seigo
AU  - Sugiyama S
FAU - Ogawa, Hisao
AU  - Ogawa H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20090514
PL  - Netherlands
TA  - J Cardiol
JT  - Journal of cardiology
JID - 8804703
RN  - 0 (Histamine H2 Antagonists)
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - 0 (Proton Pump Inhibitors)
RN  - 0 (Pyridines)
RN  - 0 (thienopyridine)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Aged
MH  - Angina Pectoris/*drug therapy
MH  - Angioplasty, Balloon, Coronary
MH  - Aspirin/adverse effects
MH  - Female
MH  - Follow-Up Studies
MH  - Gastric Mucosa/*drug effects
MH  - Gastrointestinal Hemorrhage/chemically induced
MH  - Histamine H2 Antagonists/*therapeutic use
MH  - Humans
MH  - Male
MH  - Peptic Ulcer/*chemically induced/*prevention & control
MH  - Platelet Aggregation Inhibitors/*adverse effects
MH  - Propensity Score
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Pyridines/adverse effects
MH  - Stents
EDAT- 2009/07/28 09:00
MHDA- 2011/03/11 06:00
CRDT- 2009/07/28 09:00
PHST- 2009/02/16 00:00 [received]
PHST- 2009/04/06 00:00 [revised]
PHST- 2009/04/06 00:00 [accepted]
PHST- 2009/07/28 09:00 [entrez]
PHST- 2009/07/28 09:00 [pubmed]
PHST- 2011/03/11 06:00 [medline]
AID - S0914-5087(09)00126-9 [pii]
AID - 10.1016/j.jjcc.2009.04.002 [doi]
PST - ppublish
SO  - J Cardiol. 2009 Aug;54(1):71-5. doi: 10.1016/j.jjcc.2009.04.002. Epub 2009 May 
      14.