PMID- 1963287
OWN - NLM
STAT- MEDLINE
DCOM- 19910404
LR  - 20210526
IS  - 0066-4804 (Print)
IS  - 1098-6596 (Electronic)
IS  - 0066-4804 (Linking)
VI  - 34
IP  - 10
DP  - 1990 Oct
TI  - Aminoglycoside acetyltransferase 3-IV (aacC4) and hygromycin B 4-I 
      phosphotransferase (hphB) in bacteria isolated from human and animal sources.
PG  - 1915-20
AB  - Members of the family Enterobacteriaceae harboring an enzyme of the 
      aminoglycoside acetyltransferase 3 class (AAC-3-IV) (apramycin and gentamicin 
      resistance) and hygromycin B phosphotransferase 4 (HPH-4-I) (hygromycin B 
      resistance) have been isolated from human clinical sources in Europe. A cluster 
      of genes containing IS140, aacC4, and hphB was found in these strains. We 
      demonstrate by Southern hybridization that this cluster is identical to the 
      operon found in animals that also contains insertion sequences belonging to the 
      ISO family. This provides another example of presumptive transfer of antibiotic 
      resistance genes between bacteria of animal and human origin.
FAU - Salauze, D
AU  - Salauze D
AD  - Unite de Genie Microbiologique, Institut Pasteur, Paris, France.
FAU - Otal, I
AU  - Otal I
FAU - Gomez-Lus, R
AU  - Gomez-Lus R
FAU - Davies, J
AU  - Davies J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Antimicrob Agents Chemother
JT  - Antimicrobial agents and chemotherapy
JID - 0315061
RN  - 11048-13-8 (Nebramycin)
RN  - 388K3TR36Z (apramycin)
RN  - 3XQ2233B0B (Hygromycin B)
RN  - EC 2.3.1.- (Acetyltransferases)
RN  - EC 2.3.1.- (aminoglycoside acetyltransferase)
RN  - EC 2.7.- (Phosphotransferases)
RN  - EC 2.7.1.- (Phosphotransferases (Alcohol Group Acceptor))
RN  - EC 2.7.1.119 (hygromycin-B kinase)
SB  - IM
GS  - IS140
GS  - aacC4
GS  - hphB
MH  - Acetylation/drug effects
MH  - Acetyltransferases/*genetics
MH  - Animals
MH  - Autoradiography
MH  - Cattle
MH  - Drug Resistance, Microbial
MH  - Enterobacteriaceae/*drug effects/enzymology/genetics
MH  - Genes, Bacterial/*drug effects
MH  - Humans
MH  - Hybridization, Genetic
MH  - Hygromycin B/*pharmacology
MH  - Microbial Sensitivity Tests
MH  - Nebramycin/*analogs & derivatives/pharmacology
MH  - Phosphotransferases/*genetics
MH  - *Phosphotransferases (Alcohol Group Acceptor)
MH  - Plasmids/drug effects
MH  - Transfection
PMC - PMC171964
EDAT- 1990/10/01 00:00
MHDA- 1990/10/01 00:01
PMCR- 1990/10/01
CRDT- 1990/10/01 00:00
PHST- 1990/10/01 00:00 [pubmed]
PHST- 1990/10/01 00:01 [medline]
PHST- 1990/10/01 00:00 [entrez]
PHST- 1990/10/01 00:00 [pmc-release]
AID - 10.1128/AAC.34.10.1915 [doi]
PST - ppublish
SO  - Antimicrob Agents Chemother. 1990 Oct;34(10):1915-20. doi: 
      10.1128/AAC.34.10.1915.