PMID- 19633642
OWN - NLM
STAT- MEDLINE
DCOM- 20100219
LR  - 20230210
IS  - 1530-0285 (Electronic)
IS  - 0893-3952 (Linking)
VI  - 22
IP  - 11
DP  - 2009 Nov
TI  - Diffuse blastoid B-cell lymphoma: a histologically aggressive variant of 
      t(14;18)-negative follicular lymphoma.
PG  - 1507-17
LID - 10.1038/modpathol.2009.106 [doi]
AB  - Among the diffuse lymphomas of B-cell origin, we have encountered one variant 
      displaying blastoid features that morphologically mimic lymphoblastic lymphoma, 
      the blastoid variant of mantle cell lymphoma, and the so-called blastoid 
      transformation of follicular lymphoma. To better characterize this entity, we 
      studied eight cases morphologically, immunohistochemically, and by fluorescence 
      in situ hybridization (FISH) for cytogenetic abnormalities commonly associated 
      with follicular lymphoma and B-cell lymphomas exhibiting high-grade histological 
      features. All eight cases were presented as de novo neoplasms, and displayed an 
      entirely diffuse (five cases) or only minimal follicular (three cases) growth 
      pattern. The neoplastic lymphoid cells were of medium size with round nuclei, 
      fine chromatin, inconspicuous nucleoli, and high mitotic rate; they expressed 
      CD10, BCL6, and BCL2-a phenotype consistent with follicle center cell origin. A 
      proportion of cases expressed MUM1. Their lack of TdT and CYCLIN D1 distinguished 
      them from lymphoblastic lymphoma and the blastoid mantle cell lymphoma, 
      respectively. The neoplastic lymphoid cells consistently expressed CD43 (seven of 
      eight cases) and occasionally other T-cell-associated antigens, including CD5, 
      CD7, CD8, and CD57. Although all cases overexpressed BCL2, t(14;18) was not 
      detected in any of the five cases examined by FISH; instead, extra copies of 
      chromosome 18 were found in four of five cases. Finally, other cytogenetic 
      abnormalities, including structural abnormalities of BCL6 (allelic loss/gain, 
      rearrangement), monosomy 7, del(13)(q14), and MYC allelic loss, were frequently 
      detected. The combination of a B-cell CD10+ BCL6+ BCL2+ phenotype in the presence 
      of structural abnormalities of BCL6 is consistent with a follicular center cell 
      derivation for our cases. The lack of t(14;18) seen in our cases, although rare 
      in most cases of follicular lymphoma, has been nevertheless reported in cases of 
      follicular lymphoma with a predominantly diffuse growth pattern. The molecular 
      pathogenesis, clinical manifestations, and prognostic significance of these 
      lesions remain to be elucidated.
FAU - Chiu, April
AU  - Chiu A
AD  - Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell 
      University, New York, NY 10065, USA.
FAU - Frizzera, Glauco
AU  - Frizzera G
FAU - Mathew, Susan
AU  - Mathew S
FAU - Hyjek, Elizabeth M
AU  - Hyjek EM
FAU - Chadburn, Amy
AU  - Chadburn A
FAU - Tam, Wayne
AU  - Tam W
FAU - Knowles, Daniel M
AU  - Knowles DM
FAU - Orazi, Attilio
AU  - Orazi A
LA  - eng
PT  - Journal Article
DEP - 20090724
PL  - United States
TA  - Mod Pathol
JT  - Modern pathology : an official journal of the United States and Canadian Academy 
      of Pathology, Inc
JID - 8806605
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Interferon Regulatory Factors)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (interferon regulatory factor-4)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antigens, Neoplasm/genetics/metabolism
MH  - B-Lymphocytes/metabolism
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 18/*genetics
MH  - Cytogenetic Analysis
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Interferon Regulatory Factors/genetics/metabolism
MH  - Lymphoma, B-Cell/*diagnosis/genetics/metabolism
MH  - Lymphoma, Follicular/*diagnosis/genetics/metabolism
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Proteins/genetics/metabolism
MH  - RNA, Messenger/genetics/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2009/07/28 09:00
MHDA- 2010/02/20 06:00
CRDT- 2009/07/28 09:00
PHST- 2009/07/28 09:00 [entrez]
PHST- 2009/07/28 09:00 [pubmed]
PHST- 2010/02/20 06:00 [medline]
AID - S0893-3952(22)02447-4 [pii]
AID - 10.1038/modpathol.2009.106 [doi]
PST - ppublish
SO  - Mod Pathol. 2009 Nov;22(11):1507-17. doi: 10.1038/modpathol.2009.106. Epub 2009 
      Jul 24.