PMID- 1963485
OWN - NLM
STAT- MEDLINE
DCOM- 19910409
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 120
IP  - 2
DP  - 1990 Dec 11
TI  - GABAergic mechanisms are involved in the control of tuberoinfundibular arcuate 
      neurons by the accessory olfactory bulb.
PG  - 231-3
AB  - In this study we examined electrophysiologically the involvement of the intrinsic 
      GABAergic system of the accessory olfactory bulb (AOB) in controlling the 
      activity of tuberoinfundibular (TI) arcuate neurons in anaesthetized female mice. 
      Local infusions of the gamma-aminobutyric acid-A (GABAA) receptor antagonist, 
      bicuculline into the AOB enhanced the spontaneous firing activity of TI arcuate 
      neurons with excitatory inputs from the AOB. This finding reveals a neural 
      mechanism responsible for the pregnancy blocking effect of this drug in freely 
      behaving female mice and, taken together with the cytoarchitecture of the AOB, 
      suggests that the reciprocal dendrodendritic interaction between mitral cells and 
      GABAergic granule cells in the AOB is critical to control of AOB output to TI 
      arcuate neurons as part of the final common pathway of the accessory olfactory 
      system.
FAU - Li, C S
AU  - Li CS
AD  - Department of Physiology, Kochi Medical School, Japan.
FAU - Kaba, H
AU  - Kaba H
FAU - Saito, H
AU  - Saito H
FAU - Seto, K
AU  - Seto K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Receptors, GABA-A)
RN  - Y37615DVKC (Bicuculline)
SB  - IM
MH  - Animals
MH  - Arcuate Nucleus of Hypothalamus/*physiology
MH  - Bicuculline/administration & dosage/*pharmacology
MH  - Electric Stimulation
MH  - Female
MH  - Infusions, Parenteral
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Neurons/drug effects/*physiology
MH  - Olfactory Bulb/drug effects/*physiology
MH  - Receptors, GABA-A/*physiology
EDAT- 1990/12/11 00:00
MHDA- 1990/12/11 00:01
CRDT- 1990/12/11 00:00
PHST- 1990/12/11 00:00 [pubmed]
PHST- 1990/12/11 00:01 [medline]
PHST- 1990/12/11 00:00 [entrez]
AID - 0304-3940(90)90046-C [pii]
AID - 10.1016/0304-3940(90)90046-c [doi]
PST - ppublish
SO  - Neurosci Lett. 1990 Dec 11;120(2):231-3. doi: 10.1016/0304-3940(90)90046-c.