PMID- 19635207
OWN - NLM
STAT- MEDLINE
DCOM- 20110713
LR  - 20150313
VI  - 28
IP  - 6
DP  - 2009 Jun
TI  - [Meta-analysis of fluorescence in situ hybridization and cytology for diagnosis 
      of bladder cancer].
PG  - 655-62
AB  - BACKGROUND AND OBJECTIVE: Currently, cystoscopy and urine cytology are standard 
      modalities in therapy monitoring and follow-up of bladder cancer. Cystoscopy is 
      an invasive and uncomfortable procedure while cytology has a limited value 
      because it is operator-dependent and has a low sensitivity. This study was to 
      assess the accuracy of fluorescence in situ hybridization(FISH) in detecting 
      bladder cancer by comparing it with cytology using systemic analyses of studies 
      published in both English and Chinese. METHODS: Cochrane systematic evaluation 
      was used to search through MEDLINE, EMBASE, Cochrane Library, CMCC and CNKI for 
      studies regarding FISH and cytology in the detection of bladder cancer. Data were 
      extracted and analyzed using software MetaDiSc1.4. RESULTS: In total 242 relevant 
      studies were searched, of which 12 studies were enrolled and 3430 patients were 
      included. Heterogeneity, except for threshold effects, was found within these 
      studies. A meta-analysis was performed using the random effect model. Pooled 
      accuracy indicators like sensitivity, specificity, positive likelihood ratio 
      (LR), negative LR and diagnostic odds ratio of FISH and cytology were 74% 
      (71%-77%) vs. 57% (54%-61%), 88 % (86%-90%) vs. 85 % (83%-87%), 6.18 (3.56-10.73) 
      vs. 4.15 (2.78-6.20), 0.29 (0.19-0.45) vs. 0.51(0.41-0.63) and 24.17 (9.33-62.64) 
      vs. 9.59 (5.91-15.57), respectively. The sensitivity of both FISH and cytology 
      were increased with the increase of tumor grade and stage. The areas under 
      summary receiver operating characteristics (SROC) curve were 0.8938 and 0.7847, 
      and the Q indices were 0.8247 and 0.7226 for FISH and cytology, respectively. 
      CONCLUSIONS: FISH has a high accuracy in detecting bladder cancer. But its 
      sensitivity in detecting high-stage bladder cancer is lower than that of 
      cytology. Although FISH can not replace traditional urine cytology, it can be 
      used as an important adjunct in the preoperative detection and postoperative 
      monitoring of bladder cancer.
FAU - Yang, Ming-Gen
AU  - Yang MG
AD  - Department of Urology, The Second Xiangya Hospital, Central South University, 
      Changsha, Hunan, 410011, P. R. China.
FAU - Zhao, Xiao-Kun
AU  - Zhao XK
FAU - Hou, Yi
AU  - Hou Y
FAU - Xiao, Ning
AU  - Xiao N
LA  - chi
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PT  - Meta-Analysis
PL  - China
TA  - Ai Zheng
JT  - Ai zheng = Aizheng = Chinese journal of cancer
JID - 9424852
SB  - IM
MH  - Area Under Curve
MH  - Cystoscopy
MH  - Cytodiagnosis/*methods
MH  - Databases, Bibliographic
MH  - False Negative Reactions
MH  - False Positive Reactions
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Odds Ratio
MH  - Sensitivity and Specificity
MH  - Urinary Bladder Neoplasms/*diagnosis/urine
EDAT- 2009/07/29 09:00
MHDA- 2011/07/14 06:00
CRDT- 2009/07/29 09:00
PHST- 2009/07/29 09:00 [entrez]
PHST- 2009/07/29 09:00 [pubmed]
PHST- 2011/07/14 06:00 [medline]
AID - 1000-467X200906655 [pii]
PST - ppublish
SO  - Ai Zheng. 2009 Jun;28(6):655-62.