PMID- 19635380
OWN - NLM
STAT- MEDLINE
DCOM- 20091008
LR  - 20191210
IS  - 1873-3573 (Electronic)
IS  - 0039-9140 (Linking)
VI  - 79
IP  - 5
DP  - 2009 Oct 15
TI  - On-line solid phase extraction LC-MS/MS analysis of pharmaceutical indicators in 
      water: a green alternative to conventional methods.
PG  - 1425-32
LID - 10.1016/j.talanta.2009.06.006 [doi]
AB  - A method using automated on-line solid phase extraction (SPE) directly coupled to 
      liquid chromatography/tandem mass spectrometry (LC-MS/MS) has been developed for 
      the analysis of six pharmaceuticals by isotope dilution. These selected 
      pharmaceuticals were chosen as representative indicator compounds and were used 
      to evaluate the performance of the on-line SPE method in four distinct water 
      matrices. Method reporting limits (MRLs) ranged from 10 to 25 ng/L, based on a 1 
      mL extraction volume. Matrix spike recoveries ranged from 88 to 118% for all 
      matrices investigated, including finished drinking water, surface water, 
      wastewater effluent and septic tank influent. Precision tests were performed at 
      50 and 1000 ng/L with relative standard deviations (RSDs) between 1.3 and 5.7%. A 
      variety of samples were also extracted using a traditional off-line automated SPE 
      method for comparison. Results for both extraction methods were in good 
      agreement; however, on-line SPE used approximately 98% less solvent and less 
      time. On-line SPE coupled to LC-MS/MS analysis for selected indicators offers an 
      alternative, more environmentally friendly, method for pharmaceutical analysis in 
      water by saving time and costs while reducing hazardous waste and potential 
      environmental pollution as compared with off-line SPE methods.
FAU - Trenholm, Rebecca A
AU  - Trenholm RA
AD  - Water Quality Research and Development Department, Southern Nevada Water 
      Authority, Henderson, NV 89015, USA. beck.trenholm@snwa.com
FAU - Vanderford, Brett J
AU  - Vanderford BJ
FAU - Snyder, Shane A
AU  - Snyder SA
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20090612
PL  - Netherlands
TA  - Talanta
JT  - Talanta
JID - 2984816R
RN  - 0 (Industrial Waste)
RN  - 0 (Pharmaceutical Preparations)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Chromatography, Liquid
MH  - Green Chemistry Technology
MH  - Industrial Waste/prevention & control
MH  - Pharmaceutical Preparations/*isolation & purification
MH  - Solid Phase Extraction/*methods
MH  - Tandem Mass Spectrometry
MH  - Waste Disposal, Fluid/methods
MH  - Water Pollutants, Chemical/*isolation & purification
MH  - Water Supply/standards
EDAT- 2009/07/29 09:00
MHDA- 2009/10/09 06:00
CRDT- 2009/07/29 09:00
PHST- 2009/03/20 00:00 [received]
PHST- 2009/06/01 00:00 [revised]
PHST- 2009/06/02 00:00 [accepted]
PHST- 2009/07/29 09:00 [entrez]
PHST- 2009/07/29 09:00 [pubmed]
PHST- 2009/10/09 06:00 [medline]
AID - S0039-9140(09)00440-8 [pii]
AID - 10.1016/j.talanta.2009.06.006 [doi]
PST - ppublish
SO  - Talanta. 2009 Oct 15;79(5):1425-32. doi: 10.1016/j.talanta.2009.06.006. Epub 2009 
      Jun 12.