PMID- 19635905
OWN - NLM
STAT- MEDLINE
DCOM- 20090909
LR  - 20151119
IS  - 1550-6606 (Electronic)
IS  - 0022-1767 (Linking)
VI  - 183
IP  - 4
DP  - 2009 Aug 15
TI  - Neuron-interacting satellite glial cells in human trigeminal ganglia have an APC 
      phenotype.
PG  - 2456-61
LID - 10.4049/jimmunol.0900890 [doi]
AB  - Satellite glial cells (SGC) in sensory ganglia tightly envelop the neuronal cell 
      body to form discrete anatomical units. This type of glial cell is considered 
      neuroectoderm-derived and provides physical support to neuron somata. There are 
      scattered hints in the literature suggesting that SGC have an immune-related 
      function within sensory ganglia. In this study, we addressed the hypothesis that 
      SGC are tissue-resident APC. The immune phenotype and function of a large series 
      (n = 40) of human trigeminal ganglia (TG) were assessed by detailed flow 
      cytometry, in situ analyses, and functional in vitro assays. Human TG-resident 
      SGC (TG-SGC) uniformly expressed the common leukocyte marker CD45, albeit at 
      lower levels compared with infiltrating T cells, and the macrophage markers CD14, 
      CD68, and CD11b. In addition, TG-SGC expressed the myeloid dendritic cell (DC) 
      marker CD11c, the T cell costimulatory molecules CD40, CD54, CD80, and CD86 and 
      MHC class II. However, the mature DC marker CD83 was absent on TG-SGC. 
      Functionally, TG-SGC phagocytosed fluorescent bacteria, but were unable to induce 
      an allogeneic MLR. Finally, TG-infiltrating T cells expressed the T cell 
      inhibitory molecules CD94/NKG2A and PD-1, and the interacting TG-SGC expressed 
      the cognate ligands HLA-E and PD-L1, respectively. In conclusion, the data 
      demonstrate that human TG-SGC have a unique leukocyte phenotype, with features of 
      both macrophages and immature myeloid DC, indicating that they have a role as 
      TG-resident APC with potential T cell modulatory properties.
FAU - van Velzen, Monique
AU  - van Velzen M
AD  - Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands.
FAU - Laman, Jon D
AU  - Laman JD
FAU - Kleinjan, Alex
AU  - Kleinjan A
FAU - Poot, Angelique
AU  - Poot A
FAU - Osterhaus, Albert D M E
AU  - Osterhaus AD
FAU - Verjans, Georges M G M
AU  - Verjans GM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090727
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antigen-Presenting Cells/*immunology/*metabolism
MH  - Biomarkers/metabolism
MH  - Dendritic Cells/immunology/metabolism
MH  - Escherichia coli/immunology
MH  - Humans
MH  - *Immunophenotyping
MH  - Macrophages/immunology/metabolism
MH  - Middle Aged
MH  - Myeloid Progenitor Cells/immunology/metabolism
MH  - Neurons/cytology/*immunology/metabolism
MH  - Phagocytosis/immunology
MH  - Satellite Cells, Perineuronal/*immunology/metabolism
MH  - Trigeminal Ganglion/*cytology/*immunology/metabolism
EDAT- 2009/07/29 09:00
MHDA- 2009/09/10 06:00
CRDT- 2009/07/29 09:00
PHST- 2009/07/29 09:00 [entrez]
PHST- 2009/07/29 09:00 [pubmed]
PHST- 2009/09/10 06:00 [medline]
AID - jimmunol.0900890 [pii]
AID - 10.4049/jimmunol.0900890 [doi]
PST - ppublish
SO  - J Immunol. 2009 Aug 15;183(4):2456-61. doi: 10.4049/jimmunol.0900890. Epub 2009 
      Jul 27.